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Validation of Effective Therapeutic Targets for ADPKD Using Animal Models

Authors
Woo, Yu MiKo, Je YeongLee, Eun Ji
Issue Date
Oct-2016
Publisher
SPRINGER-VERLAG SINGAPORE PTE LTD
Keywords
PKD; Animal model; Therapeutic target
Citation
CYSTOGENESIS, v.933, pp.71 - 84
Journal Title
CYSTOGENESIS
Volume
933
Start Page
71
End Page
84
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/3254
DOI
10.1007/978-981-10-2041-4_7
ISSN
0065-2598
Abstract
Various polycystic kidney disease (PKD) animal models including Pkd1- or Pkd2-deficient mice have been developed and efficiently utilized to identify novel therapeutic targets as well as elucidate multiple mechanisms of cyst formation in PKD. Based on several successful in vivo studies, preclinical approaches using PKD animal models would shed light on the development of potential therapeutic strategies for PKD. Here, we provide an update on the current evidence obtained by the in vivo evaluation of PKD therapeutic candidates and discuss the effect of therapeutic targets.
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