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Biodegradable Nitrogen-Doped Carbon Nanodots for Non-Invasive Photoacoustic Imaging and Photothermal Therapy

Authors
Lee, ChanghoKwon, WoosungBeack, SongeunLee, DonghyunPark, YoonsangKim, HyeminHahn, Sei KwangRhee, Shi-WooKim, Chulhong
Issue Date
Sep-2016
Publisher
IVYSPRING INT PUBL
Keywords
Carbon nanodot; Nitrogen doping; Photoacoustic; Photothermal; Biodegradation
Citation
THERANOSTICS, v.6, no.12, pp 2196 - 2208
Pages
13
Journal Title
THERANOSTICS
Volume
6
Number
12
Start Page
2196
End Page
2208
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/3296
DOI
10.7150/thno.16923
ISSN
1838-7640
Abstract
Multifunctional nanoparticles have been widely investigated for biomedical applications, such as imaging, therapy, and drug delivery. Especially, photoactive nanoparticles have received great attention as theranostic agents because of their heat-generating abilities after exposure to laser irradiation. However, photostability and safety issues have been the technical hurdles for further clinical applications. Here, we designed nitrogen (N)-doped carbon nanodots (N-CNDs) that have strong absorption in the near-infrared region, high photostability, and excellent biodegradability. Optimized N-CNDs can be utilized not only as a new photoacoustic (PA) imaging agent but also as a superior photothermal therapy (PTT) agent in vivo because of their strong optical absorption at a specific wavelength. We used N-CNDs to perform in vivo/ex vivo noninvasive PA imaging of sentinel lymph nodes via local delivery and performed PTT for cancer ablation therapy. Finally, biodegradation and renal clearance were confirmed by performing whole-body PA monitoring and a degradation test.
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