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Evaluation of the Biological Activity of Opuntia ficus indica as a Tissue- and Estrogen Receptor Subtype-Selective Modulator

Authors
An, Byoung HaJeong, HyesooZhou, WenmeiLiu, XiyuanKim, SoolinJang, Chang YoungKim, Hyun-SookSohn, JohannPark, Hye-JinSung, Na-HyeHong, Cheol YiChang, Minsun
Issue Date
Jun-2016
Publisher
John Wiley and Sons Ltd
Keywords
Opuntia ficus indica; flavonol; selective estrogen receptor modulator; hormone replacement therapy; menopausal symptoms; functional food
Citation
PHYTOTHERAPY RESEARCH, v.30, no.6, pp 971 - 980
Pages
10
Journal Title
PHYTOTHERAPY RESEARCH
Volume
30
Number
6
Start Page
971
End Page
980
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/3409
DOI
10.1002/ptr.5602
ISSN
0951-418X
1099-1573
Abstract
Phytoestrogens are selective estrogen receptor modulators (SERMs) with potential for use in hormone replacement therapy (HRT) to relieve peri/postmenopausal symptoms. This study was aimed at elucidating the molecular mechanisms underlying the SERM properties of the extract of Korean-grown Opuntia ficus-indica (KOFI). The KOFI extract induced estrogen response element (ERE)-driven transcription in breast and endometrial cancer cell lines and the expression of endogenous estrogen-responsive genes in breast cancer cells. The flavonoid content of different KOFI preparations affected ERE-luciferase activities, implying that the flavonoid composition likely mediated the estrogenic activities in cells. Oral administration of KOFI decreased the weight gain and levels of both serum glucose and triglyceride in ovariectomized (OVX) rats. Finally, KOFI had an inhibitory effect on the 17-estradiol-induced proliferation of the endometrial epithelium in OVX rats. Our data demonstrate that KOFI exhibited SERM activity with no uterotrophic side effects. Therefore, KOFI alone or in combination with other botanical supplements, vitamins, or minerals may be an effective and safe alternative active ingredient to HRTs, for the management of postmenopausal symptoms. Copyright (c) 2016 John Wiley & Sons, Ltd.
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이과대학 > 생명시스템학부 > 1. Journal Articles
생활과학대학 > 식품영양학과 > 1. Journal Articles
약학대학 > 약학부 > 1. Journal Articles

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생활과학대학 (식품영양학과)
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