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Axon-First Neuritogenesis on Vertical Nanowires

Authors
Kang, KyungtaePark, Yi-SeulPark, MatthewJang, Min JeeKim, Seong-MinLee, JunoChoi, Ji YuJung, Da HeeChang, Young-TaeYoon, Myung-HanLee, Jin SeokNam, YoonkeyChoi, Insung S.
Issue Date
Jan-2016
Publisher
AMER CHEMICAL SOC
Keywords
Silicon nanowires; neurite development; F-actin dynamics; primary hippocampal neuron; chemical vapor deposition; live-cell imaging
Citation
NANO LETTERS, v.16, no.1, pp 675 - 680
Pages
6
Journal Title
NANO LETTERS
Volume
16
Number
1
Start Page
675
End Page
680
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/3588
DOI
10.1021/acs.nanolett.5b04458
ISSN
1530-6984
1530-6992
Abstract
In this work, we report that high-density, vertically grown silicon nanowires (vg-SiNWs) direct a new in vitro developmental pathway of primary hippocampal neurons. Neurons on vg-SiNWs formed a single, extremely elongated major neurite earlier than minor neurites, which led to accelerated polarization. Additionally, the development of lamellipodia, which generally occurs on 2D culture coverslips, was absent on vg-SiNWs. The results indicate that surface topography is an important factor that influences neuronal development and also provide implications for the role of topography in neuronal development in vivo.
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