Detailed Information

Cited 0 time in webofscience Cited 23 time in scopus
Metadata Downloads

CTRP1 protects against diet-induced hyperglycemia by enhancing glycolysis and fatty acid oxidation

Full metadata record
DC Field Value Language
dc.contributor.authorHan, Sora-
dc.contributor.authorPark, Jeong Su-
dc.contributor.authorLee, Sunyi-
dc.contributor.authorJeong, Ae Lee-
dc.contributor.authorOh, Ki Sook-
dc.contributor.authorKa, Hye In-
dc.contributor.authorChoi, Hyun-Ji-
dc.contributor.authorSon, Woo-Chan-
dc.contributor.authorLee, Won-Young-
dc.contributor.authorOh, Suk Joong-
dc.contributor.authorLim, Jong-Seok-
dc.contributor.authorLee, Myeong-Sok-
dc.contributor.authorYang, Young-
dc.date.available2021-02-22T06:26:44Z-
dc.date.issued2016-01-
dc.identifier.issn0955-2863-
dc.identifier.issn1873-4847-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/3594-
dc.description.abstractComplement-C1q/tumor necrosis factor-alpha related protein 1 (CTRP1) is a 35-kDa glycoprotein that is secreted from various tissues. Although CTRP1 is highly increased in patients with type II diabetes and obesity, the metabolic roles of CTRP1 remain largely unknown. To unveil the physiological roles of CTRP1 in vivo, CTRP1 transgenic (TG) mice were challenged by a high-fat diet (HFD) and a high-sucrose drink (HS). Homeostatic model assessment-estimated insulin resistance values were decreased in HFD- or HS-fed CTRP1 TG mice compared with wild-type control mice. In this context, CTRP1 stimulated glucose uptake through the glucose transporter GLUT4 translocation to the plasma membrane and also increased glucose consumption by stimulating glycolysis. To analyze the roles of CTRP1 in lipid metabolism, acetyl-CoA carboxylase (ACC) and hormone-sensitive lipase levels were determined in CTRP1 TG mice, and the effect of CTRP1 on fatty acid oxidation was assessed in C2C12 myotubes. CTRP1 was found to inhibit ACC by phosphorylation and to stimulate fatty acid oxidation in C2C12 myotubes. Taken together, CTRP1 performs active catabolic roles in vivo. Therefore, CTRP1 seems to perform a defensive function against nutritional challenges. (C) 2015 Elsevier Inc. All rights reserved.-
dc.format.extent10-
dc.language영어-
dc.language.isoENG-
dc.publisherELSEVIER SCIENCE INC-
dc.titleCTRP1 protects against diet-induced hyperglycemia by enhancing glycolysis and fatty acid oxidation-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1016/j.jnutbio.2015.08.018-
dc.identifier.scopusid2-s2.0-84952760651-
dc.identifier.wosid000367409800006-
dc.identifier.bibliographicCitationJOURNAL OF NUTRITIONAL BIOCHEMISTRY, v.27, pp 43 - 52-
dc.citation.titleJOURNAL OF NUTRITIONAL BIOCHEMISTRY-
dc.citation.volume27-
dc.citation.startPage43-
dc.citation.endPage52-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaNutrition & Dietetics-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryNutrition & Dietetics-
dc.subject.keywordPlusACETYL-COA CARBOXYLASE-
dc.subject.keywordPlusINSULIN-RESISTANCE-
dc.subject.keywordPlusSKELETAL-MUSCLE-
dc.subject.keywordPlusADIPOSE-TISSUE-
dc.subject.keywordPlusGLUT4 TRANSLOCATION-
dc.subject.keywordPlusLIPID-METABOLISM-
dc.subject.keywordPlusPPAR-GAMMA-
dc.subject.keywordPlusGLUCOSE-
dc.subject.keywordPlusKINASE-
dc.subject.keywordPlusAMPK-
dc.subject.keywordAuthorHyperglycemia-
dc.subject.keywordAuthorInsulin resistance-
dc.subject.keywordAuthorHigh-sucrose diet-
dc.subject.keywordAuthorHigh-fat diet-
dc.subject.keywordAuthorGlycolysis-
dc.subject.keywordAuthorFatty acid oxidation-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/abs/pii/S0955286315002193?via%3Dihub-
Files in This Item
Go to Link
Appears in
Collections
이과대학 > 생명시스템학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Yang, Young photo

Yang, Young
이과대학 (생명시스템학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE