Anti-pancreatic cancer activity of Z-ajoene from garlic: An inhibitor of the Hedgehog/Gli/FoxM1 axis
- Authors
- Lee, Hwa Jin; Jeong, Ji Hye; Ryu, Jae-Ha
- Issue Date
- May-2019
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Ajoene; Garlic; Pancreatic cancer; Hedgehog pathway; Gli; FoxM1
- Citation
- JOURNAL OF FUNCTIONAL FOODS, v.56, pp 102 - 109
- Pages
- 8
- Journal Title
- JOURNAL OF FUNCTIONAL FOODS
- Volume
- 56
- Start Page
- 102
- End Page
- 109
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/3647
- DOI
- 10.1016/j.jff.2019.03.010
- ISSN
- 1756-4646
2214-9414
- Abstract
- Overexpression of glioma-associated oncogene (Gli), a transcription factor at the final step of Hedgehog (Hh) pathway, is involved in pancreatic cancer development. Therefore, inhibition of Gli can be a therapeutic strategy to treat pancreatic cancer. The objective of this study was to determine effects of Z-ajoene from garlic, on Gli-mediated transcription and proliferation of pancreatic cancer cells. We found that Z-ajoene could inhibit Gli transcriptional activity in Sonic Hedgehog (Shh) stimulated C3H10T1/2 mesenchymal stem cells. Z-Ajoene suppressed Gli transcriptional activity and Gli-target protein expressions in PANC-1 human pancreatic cancer cells. Z-Ajoene also reduced expression of FoxM1, one of Gli-target proteins, and subsequently down-regulated expressions of cell cycle-related proteins. Moreover, Z-ajoene reduced cell proliferation and increased G2/M phase of PANC-1 cells. These results suggest that Z-ajoene can repress pancreatic cancer cell proliferation by inhibiting Gli signaling. Thus, Z-ajoene might be a lead compound for the development of anti-pancreatic cancer agent.
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