Anti-Inflammatory Compounds from Atractylodes macrocephalaopen access
- Authors
- Jeong, Dawoon; Dong, Guang-zhi; Lee, Hwa Jin; Ryu, Jae-Ha
- Issue Date
- May-2019
- Publisher
- MDPI
- Keywords
- nitric oxide; prostaglandin E-2; inducible nitric oxide synthase; cyclooxygenase-2; nuclear factor-B; Atractylodes macrocephala
- Citation
- MOLECULES, v.24, no.10
- Journal Title
- MOLECULES
- Volume
- 24
- Number
- 10
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/3652
- DOI
- 10.3390/molecules24101859
- ISSN
- 1420-3049
- Abstract
- In relation to anti-inflammatory agents from medicinal plants, we have isolated three compounds from Atractylodes macrocephala; 1, 2-[(2E)-3,7-dimethyl-2,6-octadienyl]-6-methyl-2, 5-cyclohexadiene-1, 4-dione; 2, 1-acetoxy-tetradeca-6E,12E-diene-8, 10-diyne-3-ol; 3, 1,3-diacetoxy-tetradeca-6E, 12E-diene-8, 10-diyne. Compounds 1-3 showed concentration-dependent inhibitory effects on production of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. Western blotting and RT-PCR analyses demonstrated that compounds 1-3 suppressed the protein and mRNA levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, compounds 1-3 inhibited transcriptional activity of nuclear factor-B (NF-B) and nuclear translocation of NF-B in LPS-activated RAW 264.7 cells. The most active compound among them, compound 1, could reduce the mRNA levels of pro-inflammatory cytokines (IL-1, IL-6 and TNF-) and suppress the phosphorylation of MAPK including p38, JNK, and ERK1/2. Taken together, these results suggest that compounds 1-3 from A. macrocephala can be therapeutic candidates to treat inflammatory diseases.
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