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A coumarin-naphthalimide hybrid as a dual emissive fluorescent probe for hNQO1

Authors
Park S.Y.Won M.Kang C.Kim J.S.Lee M.H.
Issue Date
May-2019
Publisher
ELSEVIER SCI LTD
Keywords
Coumarin; Dual emission imaging; hNQO1 detection; Naphthalimide
Citation
Dyes and Pigments, v.164, pp.341 - 345
Journal Title
Dyes and Pigments
Volume
164
Start Page
341
End Page
345
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/3657
DOI
10.1016/j.dyepig.2019.01.050
ISSN
0143-7208
Abstract
hNQO1 is a promising target for cancer diagnosis and treatment. Here, we developed a coumarin-naphthalimide hybrid (1) as a dual emissive fluorescent probe that enhances the emission through hNQO1-mediated cleavage of its trimethyl lockquinone moiety. Probe 1 can be used for a real-time monitoring of hNQO1 activity in living cells. © 2019
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