Anticancer activity of gomisin J from Schisandra chinensis fruitopen access
- Authors
- Jung, Samil; Moon, Hyung-In; Kim, Subeen; Quynh, Nguyen Thi Ngoc; Yu, Jimin; Sandag, Zolzaya; Le, Dan-Diem Thi; Lee, Hyegyeong; Lee, Hyojeong; Lee, Myeong-Sok
- Issue Date
- Jan-2019
- Publisher
- SPANDIDOS PUBL LTD
- Keywords
- Schisandra chinensis fruit; gomisin J; anticancer drug; necroptosis
- Citation
- ONCOLOGY REPORTS, v.41, no.1, pp 711 - 717
- Pages
- 7
- Journal Title
- ONCOLOGY REPORTS
- Volume
- 41
- Number
- 1
- Start Page
- 711
- End Page
- 717
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/3856
- DOI
- 10.3892/or.2018.6850
- ISSN
- 1021-335X
1791-2431
- Abstract
- In attempting to identify effective anticancer drugs from natural products that are harmless to humans, we found that the gomisin J from Schisandra chinensis fruit has anticancer activity. Schisandra chinensis fruits are used in traditional herbal medicine and gomisin J is one of their chemical constituents. In the present study, we examined the anticancer activity of gomisin J in MCF7 and MDA-MB-231 breast cancer cell lines and in MCF10A normal cell line, in a time- and concentration-dependent manner. Our data revealed that gomisin J exerted a much stronger cytotoxic effect on MCF7 and MDA-MB-231 cancer cells than on MCF10A normal cells. Gomisin J suppressed the proliferation and decreased the viability of MCF7 and MDA-MB-231 cells at relatively low (<10 mu g/ml) and high (>30 mu g/ml) concentrations, respectively. Our data also revealed that gomisin J induced necroptosis, a programmed form of necrosis, as well as apoptosis. Notably, gomisin J predominantly induced necroptosis in MCF7 cells that are known to have high resistance to many pro-apoptotic anticancer drugs, while MDA-MB-231 exhibited a much lower level of necroptosis but instead a higher level of apoptosis. This data indicated the possibility that it may be used as a more effective anticancer drug, especially in apoptosis-resistant malignant cancer cells. In an extended study, gomisin J exhibited a strong cytotoxic effect on all tested various types of 13 cancer cell lines, indicating its potential to be used against a wide range of different types of cancer cells.
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