Detailed Information

Cited 0 time in webofscience Cited 10 time in scopus
Metadata Downloads

Therapeutic targeting of lipid synthesis metabolism for selective elimination of cancer stem cells

Authors
Kim, Woo-Young
Issue Date
Jan-2019
Publisher
PHARMACEUTICAL SOC KOREA
Keywords
Monounsaturated fatty acid; Cholesterol; Cancer stem cells; WNT; Notch
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.42, no.1, pp.25 - 39
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
Volume
42
Number
1
Start Page
25
End Page
39
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/3869
DOI
10.1007/s12272-018-1098-z
ISSN
0253-6269
Abstract
Cancer stem cells (CSCs) are believed to have an essential role in tumor resistance and metastasis; however, no therapeutic strategy for the selective elimination of CSCs has been established. Recently, several studies have shown that the metabolic regulation for ATP synthesis and biological building block generation in CSCs are different from that in bulk cancer cells and rather similar to that in normal tissue stem cells. To take advantage of this difference for CSC elimination therapy, many studies have tested the effect of blocking these metabolism. Two specific processes for lipid biosynthesis, i.e., fatty acid unsaturation and cholesterol biosynthesis, have been shown to be very effective and selective for CSC targets. In this review, lipid metabolism specific to CSCs are summarized. In addition, how monounsaturated fatty acid and cholesterol synthesis may contribute to CSC maintenance are discussed. Specifically, the molecular mechanism required for lipid synthesis and essential for stem cell biology is highlighted. The limit and preview of the lipid metabolism targeting for CSCs are also discussed.
Files in This Item
Go to Link
Appears in
Collections
약학대학 > 약학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Woo Young photo

Kim, Woo Young
약학대학 (약학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE