Detailed Information

Cited 0 time in webofscience Cited 1 time in scopus
Metadata Downloads

Novel Application of Radotinib for the Treatment of Solid Tumors via Natural Killer Cell Activationopen access

Authors
Kim, Kyung EunPark, SunyoungCheon, SoyoungKim, Dong YeonCho, Dae JinPark, Jeong MinHur, Dae YoungPark, Hyun JeongCho, Daeho
Issue Date
Dec-2018
Publisher
HINDAWI LTD
Citation
JOURNAL OF IMMUNOLOGY RESEARCH, v.2018
Journal Title
JOURNAL OF IMMUNOLOGY RESEARCH
Volume
2018
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4133
DOI
10.1155/2018/9580561
ISSN
2314-8861
Abstract
Radotinib (Supect) was developed to treat chronic myeloid leukemia (CML) as a BCR-ABL1 tyrosine kinase inhibitor (TKI). Other TKIs, including imatinib and nilotinib, were also developed for treatment of CML, and recent studies were increasing about the therapeutic effects of other TKIs on solid tumors. However, the effect of radotinib on solid tumors has not yet been investigated. In this study, radotinib killed CML cell line K562 directly; however, radotinib did not enhance NK cell cytotoxicity against K562 cells. Because K562 is known as a Fas-negative cell line, we investigated whether radotinib could regulate cell cytotoxicity against various Fas-expressing solid cancer cell lines. Radotinib dramatically increased NK cell cytotoxicity against various Fas-expressing solid cancer cells, including lung, breast, and melanoma cells. Additionally, the efficiency of radotinib-enhanced cytotoxicity was lower in Fas siRNA-transfected cells than in negative controls, suggesting that Fas signaling might be involved in the radotinib-enhanced NK cell cytotoxicity. This study provides the first evidence that radotinib could be used as an effective and strong therapeutic to treat solid tumors via upregulation of NK cell cytotoxicity, suggesting that radotinib has indirect killing mechanisms via upregulation of antitumor innate immune responses as well as direct killing activities for CML cells.
Files in This Item
Go to Link
Appears in
Collections
원격대학원 > 향장미용학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Kyung Eun photo

Kim, Kyung Eun
원격대학원 (향장미용학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE