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p-Coumaric acid stimulates longitudinal bone growth through increasing the serum production and expression levels of insulin-like growth factor 1 in rats

Authors
Lee, Jong HyukChung, Yoon HeeKim, Ho HyunBang, Joon SeokJung, Tae WooPark, TaekwangPark, JinwooKim, UiseokLee, Sung HoonJeong, Ji Hoon
Issue Date
Nov-2018
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
P-coumaric acid; Tibial length; Growth plate; Proliferation; Insulin-like growth factor
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.505, no.4, pp.1103 - 1106
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
505
Number
4
Start Page
1103
End Page
1106
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4180
DOI
10.1016/j.bbrc.2018.10.046
ISSN
0006-291X
Abstract
The aim of the present study was to examine the effects of p-coumaric acid on the longitudinal growth of the long bone in adolescent male rats. Teatment with p-coumaric acid significantly increased the tibial length and the height of each growth plate zone and the ratio of 5-bromo-2'-deoxyuridine-positive cells relative to total proliferative cells. Expression of insulin-like growth factor 1 and its receptor in the proliferative and hypertrophic zones, and serum levels of growth hormone and insulin-like growth factor 1 were significantly increased as well in the p-coumaric acid-treated group. Via increasing both the serum level of insulin-like growth factor 1 and its expression, p-coumaric acid could promote cell proliferation in growth plate zones. These results suggest that p-coumaric acid has the potential to increase height and may be a feasible alternative to growth hormone therapy. (C) 2018 Elsevier Inc. All rights reserved.
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