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Inhibitory and Inductive Effects of Opuntia ficus indica Extract and Its Flavonoid Constituents on Cytochrome P450s and UDP-Glucuronosyltransferasesopen access

Authors
Jeong, HyesooKim, SoolinKim, Mi-yeonLee, JiminAn, Byoung HaKim, Hee-DooJeong, HyunyoungSong, Yun SeonChang, Minsun
Issue Date
Nov-2018
Publisher
MDPI
Keywords
Opuntia ficus indica; flavonoids; drug metabolism; cytochrome P450; uridine diphosphate-glucuronosyltransferase; drug-herb interactions; menopausal women
Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.19, no.11
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume
19
Number
11
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4196
DOI
10.3390/ijms19113400
ISSN
1661-6596
1422-0067
Abstract
Opuntia ficus indica (OFI) is grown abundantly in arid areas and its fruits are regarded as an important food and nutrient source owing to the presence of flavonoids, minerals, and proteins. The previous report that OFI exerts phytoestrogenic activity makes it plausible for OFI-containing supplements to be used as alternative estrogen replacement therapy. In the case of polypharmacy with the consumption of OFI-containing botanicals in post- or peri-menopausal women, it is critical to determine the potential drug-OFI interaction due to the modulation of drug metabolism. In the present study, the modulating effects on the hepatic drug metabolizing enzymes (DMEs) by OFI and its flavonoid constituents (kaempferol, quercetin, isorhamnetin, and their glycosidic forms) were investigated using the liver microsomal fractions prepared from ovariectomized (OVX) rats, human liver microsomes, and human hepatocarcinoma cell line (HepG2). As a result, the oral administration of extracts of OFI (OFIE) in OVX rats induced hepatic CYP2B1, CYP3A1, and UGT2B1. OFIE, hydrolyzed (hdl) OFIE, and several flavonols induced the transcriptional activities of both CYP2B6 and CYP3A4 genes in HepG2 cells. Finally, OFIE did not inhibit activities of cytochrome P450 (CYPs) or uridine diphosphate (UDP)-glucuronosyltransferases (UGTs), whereas hdl OFIE or flavonol treatment inhibited CYP1A2 and CYP3A1/3A4 in rat and human liver microsomes. Our data demonstrate that OFIE may induce or inhibit certain types of DMEs and indicate that drug-OFI interaction may occur when the substrate or inhibitor drugs of specific CYPs or UGTs are taken concomitantly with OFI-containing products.
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