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Development of Biocompatible HA Hydrogels Embedded with a New Synthetic Peptide Promoting Cellular Migration for Advanced Wound Care Management

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dc.contributor.authorWang, Sun Young-
dc.contributor.authorKim, Hyosuk-
dc.contributor.authorKwak, Gijung-
dc.contributor.authorYoon, Hong Yeol-
dc.contributor.authorJo, Sung Duk-
dc.contributor.authorLee, Ji Eun-
dc.contributor.authorCho, Daeho-
dc.contributor.authorKwon, Ick Chan-
dc.contributor.authorKim, Sun Hwa-
dc.date.available2021-02-22T07:46:33Z-
dc.date.issued2018-11-
dc.identifier.issn2198-3844-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4200-
dc.description.abstractIn the past few years, there have been many efforts underway to develop effective wound healing treatments for traumatic injuries. In particular, wound-healing peptides (WHPs) and peptide-grafted dressings hold great promise for novel therapeutic strategies for wound management. This study reports a topical formulation of a new synthetic WHP (REGRT, REG) embedded in a hyaluronic acid (HA)-based hydrogel dressing for the enhancement of acute excisional wound repair. The copper-free click chemistry is utilized to form biocompatible HA hydrogels by cross-linking dibenzocyclooctyl-functionalized HA with 4-arm poly(ethylene glycol) (PEG) azide. The HA hydrogels are grafted with the REG peptide, a functional derivative of erythroid differentiation regulator1, displaying potent cell motility-stimulating ability, thus sustainably releasing physiologically active peptides for a prolonged period. Combined with the traditional wound healing benefits of HA, the HA hydrogel embedded REG (REG-HAgel) accelerates re-epithelialization in skin wound healing, particularly by promoting migration of fibroblasts, keratinocytes, and endothelial cells. REG-HAgels improve not only rate, but quality of wound healing with higher collagen deposition and more microvascular formation while being nontoxic. The peptide-grafted HA hydrogel system can be considered as a promising new wound dressing formulation strategy for the treatment of different types of wounds with combinations of various natural and synthetic WHPs.-
dc.language영어-
dc.language.isoENG-
dc.publisherWILEY-
dc.titleDevelopment of Biocompatible HA Hydrogels Embedded with a New Synthetic Peptide Promoting Cellular Migration for Advanced Wound Care Management-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1002/advs.201800852-
dc.identifier.scopusid2-s2.0-85053679980-
dc.identifier.wosid000451173200016-
dc.identifier.bibliographicCitationADVANCED SCIENCE, v.5, no.11-
dc.citation.titleADVANCED SCIENCE-
dc.citation.volume5-
dc.citation.number11-
dc.type.docTypeArticle-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.subject.keywordPlusHYALURONIC-ACID HYDROGELS-
dc.subject.keywordPlusDEGRADATION-
dc.subject.keywordPlusDELIVERY-
dc.subject.keywordPlusRELEASE-
dc.subject.keywordPlusSYSTEMS-
dc.subject.keywordAuthorbioorthogonal copper free click chemistry-
dc.subject.keywordAuthorpeptide-grafted hyaluronic acid hydrogels-
dc.subject.keywordAuthorwould healing peptides-
dc.subject.keywordAuthorwound repair-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/advs.201800852-
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