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Aqueous Extract of Humulus japonicus Attenuates Hyperlipidemia and Fatty Liver in Obese Mice

Authors
Chung, Yoon HeeBang, Joon SeokKang, Chang MukGoh, Ji WonLee, Ho SungHong, Seok MyeongKim, Dong-SeokPark, Eon SubJung, Tae WooShin, Yong KyooLee, Jong HyukJeong, Ji Hoon
Issue Date
Oct-2018
Publisher
MARY ANN LIEBERT, INC
Keywords
<bold>dyslipidemia</bold>; <bold>high-fat diet</bold>; <bold>Humulus japonicus</bold>; <bold>nonalcoholic fatty liver disease</bold>; <bold>obesity</bold>
Citation
JOURNAL OF MEDICINAL FOOD, v.21, no.10, pp 999 - 1008
Pages
10
Journal Title
JOURNAL OF MEDICINAL FOOD
Volume
21
Number
10
Start Page
999
End Page
1008
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4229
DOI
10.1089/jmf.2017.4135
ISSN
1096-620X
1557-7600
Abstract
In this study, the effects of Humulus japonicus (HJ) aqueous extract on 3T3-L1 preadipocytes and HepG2 cells (in vitro model) as well as on C57BL/6 mice fed on high-fat diet (HFD) (in vivo model) were evaluated. Mice fed on HFD for 12-weeks were taken the HJ water extract (HJW) at various doses, 50, 150, and 250mg/kg, orally for 8 weeks. We have noticed the accumulation of fat globules in preadipocytes and HepG2 cells using Oil Red O staining. In addition, supplementation with HJW considerably inhibited the weight gain, lipid accumulation, and adipogenesis and decreased the size of subcutaneous adipocytes in 3T3-L1 adipocytes. Furthermore, treatment with HJW improved hyperlipidemia via decreasing the levels of serum triglyceride (TG) and low-density lipoproteins as well as the atherogenic index. Supplementation with HJW could attenuate HFD-induced lipid accumulation, increase the mRNA expressions of fatty acid synthase (FAS) and stearoyl-CoA desaturase (SCD1), and would elevate the levels of serum aspartate aminotransferase and alanine aminotransferase in mice liver. The levels of TG and FAS mRNA in HepG2 cells treated with palmitate were reduced in a dose-dependent manner. In sum, HJW could alleviate the HFD-induced obesity and decrease the dyslipidemia profiles; the keys that could contribute to cardiovascular and nonalcoholic liver diseases.
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