고령자에서 Sulfonylureas와 항균제의 병용투여 현황
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이세라 | - |
dc.contributor.author | 옥미영 | - |
dc.contributor.author | 김현아 | - |
dc.date.available | 2021-02-22T08:45:41Z | - |
dc.date.issued | 2018-09 | - |
dc.identifier.issn | 1226-6051 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4274 | - |
dc.description.abstract | Background: Previous studies have noted that the simultaneous use of sulfonylureas and antimicrobials, which is common, couldincrease the risk of hypoglycemia. In particular, an age of 65 years or older is a known risk factor for sulfonylurea-relatedhypoglycemia in hospitalized patients. Therefore, we performed this study to determine the potential risk of hypoglycemia from theconcurrent use of antimicrobials and sulfonylureas. Methods: We performed a cross-sectional study on the National HealthInsurance Service-National Sample Cohort from 2013. The eligibility criteria included patients of 65 years of age or older taking asulfonylurea with 25 different antimicrobials. Different risk ratings of severity in drug-drug interactions (potential DDIs), level X, D, orC in Lexi-Interact™online, and contraindicated, major, or moderate severity level in Micromedex® were included. SAS version 9.4was used for data analysis. Results: A total of 6,006 elderly patients with 25,613 prescriptions were included. The largest age groupwas 70 to 74 (32.7%), and 39.7% of patients were men. The mean number of prescriptions was 4.3 per patient. The most frequentlyused antimicrobials were levofloxacin (6,583, 25.7%), ofloxacin (6,549, 25.6%), fluconazole (4,678, 18.0%), and ciprofloxacin (2,551,9.8%). Among sulfonylureas, glimepiride was prescribed most frequently, followed by gliclazide, glibenclamide, and glipizide. Conclusion: Of the antimicrobials with a high potential of hypoglycemia, levofloxacin, ofloxacin, fluconazole, and ciprofloxacin wereused frequently. Thus, the monitoring of clinically relevant interactions is required for patients concurrently administered sulfonylureasand antimicrobials. | - |
dc.format.extent | 6 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 한국임상약학회 | - |
dc.title | 고령자에서 Sulfonylureas와 항균제의 병용투여 현황 | - |
dc.title.alternative | Concurrent Use of Sulfonylureas and Antimicrobials of the Elderly in Korea: A Potential Risk of Hypoglycemia | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.24304/kjcp.2018.28.3.167 | - |
dc.identifier.bibliographicCitation | 한국임상약학회지, v.28, no.3, pp 188 - 193 | - |
dc.citation.title | 한국임상약학회지 | - |
dc.citation.volume | 28 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 188 | - |
dc.citation.endPage | 193 | - |
dc.identifier.kciid | ART002389738 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Sulfonylurea compounds | - |
dc.subject.keywordAuthor | anti-infective agents | - |
dc.subject.keywordAuthor | hypoglycemia | - |
dc.subject.keywordAuthor | drug interactions | - |
dc.identifier.url | http://www.ekjcp.org/journal/view.html?doi=10.24304/kjcp.2018.28.3.167 | - |
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