Salvia miltiorrhiza enhances the survival of mesenchymal stem cells under ischemic conditionsopen access
- Authors
- Kim, Ran; Lee, Seokyeon; Lee, Chang Youn; Yun, Hwayoung; Lee, Hojin; Lee, Min Young; Kim, Jongmin; Jeong, Jee-Yeong; Baek, Kyungmin; Chang, Woochul
- Issue Date
- Sep-2018
- Publisher
- WILEY
- Keywords
- brain ischemic stroke; cell survival; mesenchymal stem cells; Salvia miltiorrhiza extract
- Citation
- JOURNAL OF PHARMACY AND PHARMACOLOGY, v.70, no.9, pp 1228 - 1241
- Pages
- 14
- Journal Title
- JOURNAL OF PHARMACY AND PHARMACOLOGY
- Volume
- 70
- Number
- 9
- Start Page
- 1228
- End Page
- 1241
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4279
- DOI
- 10.1111/jphp.12950
- ISSN
- 0022-3573
2042-7158
- Abstract
- ObjectivesTo validate the enhanced therapeutic effect of Salvia miltiorrhiza Bunge (SM) for brain ischemic stroke through the anti-apoptotic and survival ability of mesenchymal stem cells (MSCs). MethodsThe viability and the expression level of cell apoptotic and survival-related proteins in MSCs by treatment of SM were assessed in vitro. In addition, the infarcted brain region and the behavioural changes after treatment of MSCs with SM were confirmed in rat middle cerebral artery occlusion (MCAo) models. Key findingsWe demonstrated that SM attenuates apoptosis and improves the cell viability of MSCs. In the rat MCAo model, the recovery of the infarcted region and positive changes of behaviour are observed after treatment of MSCs with SM. ConclusionsThe therapy using SM enhances the therapeutic effect for brain ischemic stroke by promoting the survival of MSCs. This synergetic effect thereby proposes a new experimental approach of traditional Chinese medicine and stem cell-based therapies for patients suffering from a variety of diseases.
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