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Exosomes derived from microRNA-584 transfected mesenchymal stem cells: novel alternative therapeutic vehicles for cancer therapyopen access

Authors
Kim, RanLee, SeokyeonLee, JihyunKim, MinjiKim, Won JungLee, Hee WonLee, Min YoungKim, JongminChang, Woochul
Issue Date
Aug-2018
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Keywords
Cancer therapy; Exosomes; Glioma; Mesenchymal stem cells; MicroRNA
Citation
BMB REPORTS, v.51, no.8, pp 406 - 411
Pages
6
Journal Title
BMB REPORTS
Volume
51
Number
8
Start Page
406
End Page
411
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4378
DOI
10.5483/BMBRep.2018.51.8.105
ISSN
1976-6696
1976-670X
Abstract
Exosomes are small membranous vesicles which contain abundant RNA molecules, and are transferred from releasing cells to uptaking cells. MicroRNA (miRNA) is one of the transferred molecules affecting the adopted cells, including glioma cells. We hypothesized that mesenchymal stem cells (MSCs) can secrete exosomes loading miRNA and have important effects on the progress of gliomas. To determine these effects by treating exosomal miRNA in culture media of miRNA mimic transfected MSCs, we assessed the in vitro cell proliferation and invasion capabilities, and the expression level of relative proteins associated with cell apoptosis, growth and migration. For animal studies, the mice injected with U87 cells were exposed to exosomes derived from miRNA-584-5p transfected MSCs, to confirrn the influence of exosomal miRNA on the progress of glioma. Based on our results, we propose a new targeted cancer therapy wherein exosomes derived from miRNA transfected MSCs could be used to modulate tumor progress as the anticancer vehicles.
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