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Bisphenol A and estradiol impede myoblast differentiation through down-regulating Akt signaling pathway

Authors
Go, Ga-YeonLee, Sang-JinJo, AyoungLee, Jae-RinKang, Jong-SunYang, MihiBae, Gyu-Un
Issue Date
Aug-2018
Publisher
ELSEVIER IRELAND LTD
Keywords
Bisphenol A; Estradiol; Myoblast differentiation; Akt signaling
Citation
TOXICOLOGY LETTERS, v.292, pp 12 - 19
Pages
8
Journal Title
TOXICOLOGY LETTERS
Volume
292
Start Page
12
End Page
19
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4389
DOI
10.1016/j.toxlet.2018.04.019
ISSN
0378-4274
1879-3169
Abstract
Bisphenol A (BPA), one of the most widespread endocrine disrupting chemicals, is known as an artificial estrogen, which interacts with estrogen receptor (ER). In this study, we investigated the effects of BPA and estradiol on myoblast differentiation and the underlying signaling mechanism. Exposure to BPA (0.01-1 mu M) in mouse myoblast C2C12 cells attenuated myogenic differentiation via the reduced expression of muscle-specific genes, such as myosin heavy chain (MHC), MyoD, and Myogenin, without the alteration of cell proliferation and viability. BPA-exposed C2C12 myoblasts also showed a reduction of Akt phosphorylation ((37-61) %, p < 0.001), a key event for myogenesis. Similarly to BPA, estradiol (0.01-1 mu M) reduced the expression of muscle-specific proteins and the formation of multinucleated myotubes, and attenuated the muscle differentiation- specific phosphorylation of Akt ((42-59) %, p < 0.001). We conclude that BPA and estradiol suppress myogenic differentiation through the inhibition of Akt signaling.
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