The functional roles of PML nuclear bodies in genome maintenance
- Authors
- Chang, Hae Ryung; Munkhjargal, Anudari; Kim, Myung-Jin; Park, Seon Young; Jung, Eunyoung; Ryu, Jae-Ha; Yang, Young; Lim, Jong-Seok; Kim, Yonghwan
- Issue Date
- May-2018
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- PML nuclear body; SUMOylation; DNA repair; Genome maintenance
- Citation
- MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, v.809, pp 99 - 107
- Pages
- 9
- Journal Title
- MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Volume
- 809
- Start Page
- 99
- End Page
- 107
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4536
- DOI
- 10.1016/j.mrfmmm.2017.05.002
- ISSN
- 0027-5107
1873-135X
- Abstract
- In the nucleus, there are several membraneless structures called nuclear bodies. Among them, promyelocytic leukemia nuclear bodies (PML-NBs) are involved in multiple genome maintenance pathways including the DNA damage response, DNA repair, telomere homeostasis, and p53-associated apoptosis. In response to DNA damage, PML-NBs are coalesced and divided by a fission mechanism, thus increasing their number. PML-NBs also play a role in repairing DNA double-strand breaks (DSBs) by homologous recombination (HR). Clinically, the dominant negative PML-RARa fusion protein expressed in acute promyelocytic leukemia (APL) inhibits the transactivation of downstream factors and disrupts PML function, revealing the tumor suppressor role of PML-NBs. All-trans retinoic acid and arsenic trioxide treatment has been implemented for promyelocytic leukemia to target the PML-RARa fusion protein. PML-NBs are associated with various factors implicated in genome maintenance, and are found at the sites of DNA damage. Their interaction with proteins such as p53 indicates that PML-NBs may play a significant role in apoptosis and cancer. Decades of research have revealed the importance of PML-NBs in diverse cellular pathways, yet the underlying molecular mechanisms and exact functions of PML-NBs remain elusive. In this review, PML protein modifications and the functional relevance of PML-NB and its associated factors in genome maintenance will be discussed.
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