Detailed Information

Cited 0 time in webofscience Cited 16 time in scopus
Metadata Downloads

Eupatilin with PPAR alpha agonistic effects inhibits TNF alpha-induced MMP signaling in HaCaT cells

Authors
Jung, YujungKim, Jin-ChulChoi, YongsooLee, SullimKang, Ki SungKim, Yong KeeKim, Su-Nam
Issue Date
Nov-2017
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Eupatilin; PPAR alpha; MMPs; NF-kappa B; AP-1
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.493, no.1, pp 220 - 226
Pages
7
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
493
Number
1
Start Page
220
End Page
226
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/5068
DOI
10.1016/j.bbrc.2017.09.043
ISSN
0006-291X
1090-2104
Abstract
Eupatilin (5,7-dihydroxy-3,4,6-trimethoxyflavone) is a flavonoid compound exhibiting several beneficial biological activities, including neuroprotection, anti-cancer, antinociception, chondroprotection, anti oxidation, and anti-inflammation. Our previous study demonstrated that eupatilin specifically activates peroxisome proliferator-activated receptor alpha (PPAR alpha) through direct binding. The PPAR subfamily includes ligand-dependent transcription factors that consist of three isotypes: PPAR alpha, PPAR beta/delta, and PPAR gamma. All isotypes are involved in inflammation, epidermal proliferation/differentiation and skin barrier function. Among them, PPAR alpha regulates lipid and glucose metabolism and skin homeostasis. In this study, we confirm that the ability of eupatilin as a PPAR alpha activator significantly inhibited tumor necrosis factor-alpha (TNF alpha)-induced matrix metalloproteinase (MMP)-2/-9 expression and proteolytic activity in HaCaT human epidermal keratinocytes. Furthermore, we found that eupatilin subsequently suppressed I kappa B alpha phosphorylation, blocked NF-kappa B p65 nuclear translocation and down-regulated MAPK/AP-1 signaling via PPAR alpha activation. Taken together, our data suggest that eupatilin inhibits TNF alpha-induced MMP-2/-9 expression by suppressing NF-kappa B and MAPK/AP-1 pathways via PPAR alpha. Our findings suggest the usefulness of eupatilin for preventing skin aging. (C) 2017 Elsevier Inc. All rights reserved.
Files in This Item
Go to Link
Appears in
Collections
약학대학 > 약학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Yong Kee photo

Kim, Yong Kee
약학대학 (약학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE