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Use of Moderate-Intensity Statins for Low-Density Lipoprotein Cholesterol Level above 190mg/dL at Baseline in Koreansopen access

Authors
Kim, Hun-SungLee, HyeseonLee, Sue HyunJeong, Yoo JinKim, Tong MinYang, So JungBaik, Sun JungKim, HyunahLee, Seung-HwanCho, Jae HyoungChoi, In-YoungYoon, Kun-HoKim, Ju Han
Issue Date
Oct-2017
Publisher
WILEY
Citation
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, v.121, no.4, pp 272 - 278
Pages
7
Journal Title
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Volume
121
Number
4
Start Page
272
End Page
278
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/5108
DOI
10.1111/bcpt.12765
ISSN
1742-7835
1742-7843
Abstract
The ACC/AHA 2013 guideline recommends high-intensity statin therapy for a decrease in low-density lipoprotein cholesterol (LDL-C) level by >50% among patients with baseline values of 190mg/dL (approximately 4.872mmol/L); however, this value should be modified before applying it to Korean populations. We investigated the statin-specific LDL-C-lowering effects in Korean patients with baseline LDL-C value 4.872mmol/L. Data of patients prescribed a statin for the first time from January 2009 to December 2013 were assessed. In patients with baseline LDL-C value 4.872mmol/L, laboratory data for a maximum of 6months from the date of first statin prescription were collected. Among 33,721 patients who were prescribed a statin for the first time, 655 patients had a baseline LDL-C value 4.872mmol/L (1.9%). Of these, 179 patients were analysed. Patients receiving moderate-intensity statins were divided into two groups based on LDL-C reduction rate (p=0.0002), defined as moderate-high-intensity (atorvastatin 20mg, rosuvastatin 10mg, simvastatin 20mg) and moderate-low-intensity (atorvastatin 10mg, pitavastatin 2mg, pravastatin 40mg) statin groups. LDL-C reduction rates did not significantly differ between the moderate-high- and high-intensity statin groups (p=0.4895). We found that some moderate-intensity statins demonstrated a LDL-C-lowering effect of more than 50% in Korean patients with a baseline LDL-C value 4.872mmol/L. Our results reflect the need of a large-scale, randomized, controlled trial on partial reclassification of statins for patients with baseline LDL-C value 4.872mmol/L before adopting ACC/AHC guidelines in Korea.
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