Acacetin의 HeLa 세포 Apoptosis 유도 효과Effect of Acacetin on the Apoptosis Induction of HeLa Cells
- Other Titles
- Effect of Acacetin on the Apoptosis Induction of HeLa Cells
- Authors
- 한수정; 김안근
- Issue Date
- Feb-2015
- Publisher
- 대한약학회
- Keywords
- HeLa cells; acacetin; apoptosis
- Citation
- 약 학 회 지, v.59, no.1, pp 17 - 22
- Pages
- 6
- Journal Title
- 약 학 회 지
- Volume
- 59
- Number
- 1
- Start Page
- 17
- End Page
- 22
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/5561
- DOI
- 10.17480/psk.2015.59.1.17
- ISSN
- 0377-9556
- Abstract
- In this study, we examined the effect of acacetin on the apoptosis induction of HeLa human cervical cancercells. The results showed that acacetin inhibited the cell viability and induced apoptosis, leading to PARP cleavage and activationof caspase-9, -3, and -7. Moreover, acacetin-induced apoptosis was attenuated by a broad caspase inhibitor, z-VADfmk.
Also, acacetin resulted in a loss of mitochondria membrane potential. Taken together, our results demonstrate that theinduction of apoptosis by acacetin in HeLa cells is associated with caspase activation via the mitochondria pathway.
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