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Acacetin의 HeLa 세포 Apoptosis 유도 효과Effect of Acacetin on the Apoptosis Induction of HeLa Cells

Other Titles
Effect of Acacetin on the Apoptosis Induction of HeLa Cells
Authors
한수정김안근
Issue Date
Feb-2015
Publisher
대한약학회
Keywords
HeLa cells; acacetin; apoptosis
Citation
약 학 회 지, v.59, no.1, pp 17 - 22
Pages
6
Journal Title
약 학 회 지
Volume
59
Number
1
Start Page
17
End Page
22
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/5561
DOI
10.17480/psk.2015.59.1.17
ISSN
0377-9556
Abstract
In this study, we examined the effect of acacetin on the apoptosis induction of HeLa human cervical cancercells. The results showed that acacetin inhibited the cell viability and induced apoptosis, leading to PARP cleavage and activationof caspase-9, -3, and -7. Moreover, acacetin-induced apoptosis was attenuated by a broad caspase inhibitor, z-VADfmk. Also, acacetin resulted in a loss of mitochondria membrane potential. Taken together, our results demonstrate that theinduction of apoptosis by acacetin in HeLa cells is associated with caspase activation via the mitochondria pathway.
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