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호장으로부터 분리한 스틸벤류의 Nitric Oxide 저해활성Inhibition of Nitric Oxide Production by Stilbenes from Polygonum cuspidatum

Other Titles
Inhibition of Nitric Oxide Production by Stilbenes from Polygonum cuspidatum
Authors
주시몽홍윤정양기숙
Issue Date
Feb-2014
Publisher
대한약학회
Keywords
Polygonum cuspidatum; resveratrol; trans-resveratrol 3-O-β-D-glucopyranoside; antiinflammatory agents
Citation
약 학 회 지, v.58, no.1, pp 12 - 15
Pages
4
Journal Title
약 학 회 지
Volume
58
Number
1
Start Page
12
End Page
15
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/6056
ISSN
0377-9556
Abstract
Polygonum cuspidatum which is widely distributed in Korea has been used as treatments of dermatitis, gonorrhea,favus athlete's foot, hyperlipidemia and inflammation in traditional medicine. We examined anti-oxidant and antiinflammatoryactivity by measuring DPPH radical scavenging activity and the inhibition of IFN-γ and LPS-induced NO productionin RAW 264.7 murine macrophage cells. We isolated and characterized resveratrol (1), trans-resveratrol 3-O-β-Dglucopyranoside(2). Compounds 1 and 2 showed potent activities compared with L-NMMA (NG-monomethyl-L-arginine). These results suggested that the stilbene compounds isolated from Polygonum cuspidatum might be used as antiinflammatoryagents.
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