호장으로부터 분리한 스틸벤류의 Nitric Oxide 저해활성Inhibition of Nitric Oxide Production by Stilbenes from Polygonum cuspidatum
- Other Titles
- Inhibition of Nitric Oxide Production by Stilbenes from Polygonum cuspidatum
- Authors
- 주시몽; 홍윤정; 양기숙
- Issue Date
- Feb-2014
- Publisher
- 대한약학회
- Keywords
- Polygonum cuspidatum; resveratrol; trans-resveratrol 3-O-β-D-glucopyranoside; antiinflammatory agents
- Citation
- 약 학 회 지, v.58, no.1, pp 12 - 15
- Pages
- 4
- Journal Title
- 약 학 회 지
- Volume
- 58
- Number
- 1
- Start Page
- 12
- End Page
- 15
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/6056
- ISSN
- 0377-9556
- Abstract
- Polygonum cuspidatum which is widely distributed in Korea has been used as treatments of dermatitis, gonorrhea,favus athlete's foot, hyperlipidemia and inflammation in traditional medicine. We examined anti-oxidant and antiinflammatoryactivity by measuring DPPH radical scavenging activity and the inhibition of IFN-γ and LPS-induced NO productionin RAW 264.7 murine macrophage cells. We isolated and characterized resveratrol (1), trans-resveratrol 3-O-β-Dglucopyranoside(2). Compounds 1 and 2 showed potent activities compared with L-NMMA (NG-monomethyl-L-arginine). These results suggested that the stilbene compounds isolated from Polygonum cuspidatum might be used as antiinflammatoryagents.
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