8-Oxo-2 '-deoxyguanosine ameliorates features of metabolic syndrome in obese mice
- Authors
- Ko, Seong-Hee; Lee, Jin-Ku; Lee, Hyun Joo; Ye, Sang-Kyu; Kim, Hyun-Sook; Chung, Myung-Hee
- Issue Date
- Jan-2014
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Metabolic syndrome; Insulin resistance; Inflammation; 8-Oxo-deoxyguanosine
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.443, no.2, pp 610 - 616
- Pages
- 7
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 443
- Number
- 2
- Start Page
- 610
- End Page
- 616
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/6168
- DOI
- 10.1016/j.bbrc.2013.12.018
- ISSN
- 0006-291X
1090-2104
- Abstract
- Metabolic syndrome describes a group of clinical features that together increase the incidence of coronary artery disease, stroke and type 2 diabetes. Insulin resistance is a major risk factor for developing metabolic syndrome. A chronic state of inflammation accompanies the accumulation of surplus lipids in adipose and liver tissue, frequently involved in insulin resistance. 8-Oxo-2'-deoxyguanosine (8-Oxo-dG) is a potent anti-inflammatory agent that inactivates both Rac1 and Rac2 which are critical to initiating the inflammatory responses in various cell types, including macrophages. In this study, we explored whether 8-Oxo-dG suppressed a series of systemic inflammatory cascades, resulting in the amelioration of typical features of metabolic syndrome in obese mice. The results demonstrate that 8-Oxo-dG effectively improved hyperglycemia, dyslipidemia and fatty liver changes in obese mice. The level of biochemical markers indicative of systemic inflammation were reduced in 8-Oxo-dG treated mice, whereas serum levels of adiponectin, a crucial factor associated with improved metabolic syndrome, were enhanced. Our results demonstrate that 8-Oxo-dG effectively disrupts the pathogenesis of insulin resistance and obesity-associated metabolic syndrome. (C) 2013 Elsevier Inc. All rights reserved.
- Files in This Item
-
Go to Link
- Appears in
Collections - 생활과학대학 > 식품영양학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.