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RBL-2H3 세포에서 Cyanidin-3-glucoside의 Th2 사이토카인 발현 억제 효과Suppressive Effects of Cyanidin-3-glucoside on Th2 Cytokines Production in RBL-2H3 Cells

Other Titles
Suppressive Effects of Cyanidin-3-glucoside on Th2 Cytokines Production in RBL-2H3 Cells
Authors
정화현윤수정표명윤
Issue Date
Oct-2013
Publisher
대한약학회
Keywords
cyanidin-3-glucoside; IL-4; IL-13; RBL-2H3 cells; antiallergy
Citation
약 학 회 지, v.57, no.5, pp 309 - 315
Pages
7
Journal Title
약 학 회 지
Volume
57
Number
5
Start Page
309
End Page
315
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/6256
ISSN
0377-9556
Abstract
Cyanidin-3-glucoside (C3G), an anthocyanin, is one of the most widespread dietary flavonoids. We investigatedthe effects of C3G in PMA/ionomycin (PI)-induced RBL-2H3 cells. C3G inhibited the production of IL-4 and IL-13 and alsodecreased the level of mRNA in a dose-dependent manner. Furthermore, western blot analysis implied that C3G down-regulatedthe protein level of c-Jun, NF-ATc1 and NF-κB but not c-Fos. Taken together, we suggest that C3G may have suppressiveeffects on Th2 cytokines and will be studied further to develop as functional foods that help alleviate allergysymptoms.
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