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Anti-allergic effect of low molecular weight beta-glucan prepared by lambda-irradiation
- Authors
- Sung, Nak-Yun; Choi, Jong-il; Yoon, Yohan; Lee, Soo-Young; Byun, Myung-Woo; Hwang, Yeoung-Jung; Koenari, Zubaidah Irawati; Lee, Ju-Woon; Kim, Jae-Hun
- Issue Date
- Jun-2011
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- allergy; beta-glucan; low molecular weight; cytokine
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.20, no.3, pp 841 - 844
- Pages
- 4
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 20
- Number
- 3
- Start Page
- 841
- End Page
- 844
- ISSN
- 1226-7708
2092-6456
- Abstract
- This study evaluated the anti-allergic effect of low molecular weight beta-glucan (25 kDa) degraded by lambda-irradiation. Allergy was induced in mouse models administrated with lambda-irradiated low molecular weight and non-irradiated high molecular weight beta-glucan, respectively, for 7 days. However, only the mice treated with low molecular weight beta-glucan had a significantly decreased the total serum IgE and ovalbumin specific-IgE levels, and significantly increased Th 1 cytokine expression compared to only allergy induced mice. The allergic responses could be reduced by low molecular weight beta-glucan treated lambda-irradiation through the increased expression of Th 1 response and decreased expression of total IgE and antigen specific IgE.
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