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ADHD 환자에 대한 OROS-Methylphenidate 약물치료의 부작용과 관련요인들에 대한 연구The Side Effects and Correlates of OROS-Methylphenidate in the Treatment of Children and Adolescents with ADHD

Other Titles
The Side Effects and Correlates of OROS-Methylphenidate in the Treatment of Children and Adolescents with ADHD
Authors
김진선김붕년조수철신민섭유희정김재원송동호신동원정유숙천근아신의진김예니하은혜
Issue Date
Jun-2010
Publisher
대한소아청소년 정신의학회
Keywords
ADHD·OROS-MPH·부작용·약물반응.; ADHD·OROS-MPH·Side Effects·Drug Response.
Citation
소아 청소년 정신의학, v.21, no.2, pp.63 - 71
Journal Title
소아 청소년 정신의학
Volume
21
Number
2
Start Page
63
End Page
71
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/7306
ISSN
1225-729X
Abstract
Objectives:The aim of this study was to investigate the effect of the clinical and demographic variables such as body weight, dosage, family history of attention-deficit hyperactivity disorder (ADHD), and psychiatric co-morbidity on the side-effects of OROS-Methylphenidate (OROS-MPH), and to evaluate the relationship between drug response and side effect severity. Methods:A total of 144 children (ages 6-18) with diagnosed ADHD were treated with OROS-MPH. Children were examined at baseline and after 1, 3, 6, 9, and 12 weeks of each treatment condition. The stimulant drug side effect rating scale (SERS), pulse rate, systolic blood pressure, diastolic blood pressure, and electrocardiogram (ECG) were evaluated to assess side effect profiles. Changes in these parameters from baseline were examined and analyzed. Results:Anorexia (30.95%) and insomnia (13.10%) were the most commonly reported side effects during this study. Insomnia and loss of appetite score increased at one week follow-up, but was sustained or decreased as treatment progressed. Small but significant increases in pulse rate and diastolic blood pressure were observed during treatment;however, no clinically meaningful changes in ECG parameters were noted during the study. Low body weight, high dosage of OROS-MPH, and family history of ADHD were associated with cardiovascular side effect. In contrast, there was no significant relationship between OROS-MPH treatment response and the severity of side effect and no difference resulted between the responder and non-responder groups with respect to OROS-MPH dosage in the 12 weeks of follow-up. Conclusion:To the best of our knowledge, this study is the first Korean study to investigate comprehensive side effect profiles and their correlates in OROS-MPH treatment for ADHD children. OROS-MPH was well tolerated with no clinically significant side effects during the treatment period. In conclusion, low body weight, high dosage of OROSMPH, and family history of ADHD could be used as predictive factors in increasing pulse rate and blood pressure.
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생활과학대학 (아동복지학부)
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