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TRPVl antagonist로서의 2-( 4-tert-butylphenoxy }-N-(3-fluoro-4-methanesulfonylaminobenzyl)-N’:"'hydroxyacetamidine의 분자 설계 및 합성
- Issue Date
- Dec-2008
- Publisher
- 숙명여자대학교 약학연구소
- Citation
- 약학논문집-숙명여자대학교, v.24, pp 22 - 26
- Journal Title
- 약학논문집-숙명여자대학교
- Volume
- 24
- Start Page
- 22
- End Page
- 26
- ISSN
- 1225-3723
- Abstract
- 2-(4-ter7-butylphenoxy }-N-(3-fluoro~4-methanesulfonylaminobenzyl)-N’-hydroxyacetamidine (16) was designed, synthesized and evaluated as a TRPVI antagonist. Amidine group was introduced as a bioisaster of amide to improve the pharmacological profile. Compound 9 showed an antagonist activity with 2.8 pM of ICw value in °Ca’’-influx assay.
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