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다환성 방향족 탄화수소의 직업적 노출에 대한 한국산 배의 화학적 암예방 가능성: 서울에서 근무하는 일부 택시운전자 연구Chemopreventive Potentials of Korean Pears Against Occupational PAHs-Exposure: A Study Among Taxi Drivers in Seoul

Other Titles
Chemopreventive Potentials of Korean Pears Against Occupational PAHs-Exposure: A Study Among Taxi Drivers in Seoul
Authors
이호선양미희
Issue Date
Mar-2009
Publisher
대한암예방학회
Keywords
Korean pears; Taxi drivers; PAHs; 1-OHP; Chemopreventive effects
Citation
대한암예방학회지, v.14, no.1, pp.16 - 19
Journal Title
대한암예방학회지
Volume
14
Number
1
Start Page
16
End Page
19
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/7655
ISSN
2288-3649
Abstract
Polycyclic aromatic hydrocarbons (PAHs) originate from incomplete combustion of carbohydrate compounds. Particularly, occupational exposure to high PAHs has been suspected to induce cancer. In addition, consumption of the Korean pears showed inverse association with level of urinary 1-hydroxypyrene (1-OHP), which is an exposure biomarker and metabolite of PAHs. Therefore, we investigated the effects of the Korean pears on level of urinary 1-OHP among male taxi drivers at Seoul, in a pilot study (for 3 days; N=6 of male smokers; age, 51.67±11.55 yrs). According to results, we found that the Korean pears stimulated excretion of urinary 1-OHP during 24 hrs compared to that without the pears. There were significant differences in 1-OHP levels due to ‘the pear intake and time course’ (p <0.001). In conclusion, our results suggest that the Korean pears may have chemopreventive effects on PAHs-induced cancer, particularly PAHs-high exposed people, via rapid excretion of bioactive intermediates.
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