다환성 방향족 탄화수소의 직업적 노출에 대한 한국산 배의 화학적 암예방 가능성: 서울에서 근무하는 일부 택시운전자 연구Chemopreventive Potentials of Korean Pears Against Occupational PAHs-Exposure: A Study Among Taxi Drivers in Seoul
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- Chemopreventive Potentials of Korean Pears Against Occupational PAHs-Exposure: A Study Among Taxi Drivers in Seoul
- 이호선; 양미희
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- Korean pears; Taxi drivers; PAHs; 1-OHP; Chemopreventive effects
- 대한암예방학회지, v.14, no.1, pp.16 - 19
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- Polycyclic aromatic hydrocarbons (PAHs) originate from incomplete combustion of carbohydrate compounds. Particularly, occupational exposure to high PAHs has been suspected to induce cancer. In addition, consumption of the Korean pears showed inverse association with level of urinary 1-hydroxypyrene (1-OHP), which is an exposure biomarker and metabolite of PAHs. Therefore, we investigated the effects of the Korean pears on level of urinary 1-OHP among male taxi drivers at Seoul, in a pilot study (for 3 days; N=6 of male smokers; age, 51.67±11.55 yrs). According to results, we found that the Korean pears stimulated excretion of urinary 1-OHP during 24 hrs compared to that without the pears. There were significant differences in 1-OHP levels due to ‘the pear intake and time course’ (p ＜0.001). In conclusion, our results suggest that the Korean pears may have chemopreventive effects on PAHs-induced cancer, particularly PAHs-high exposed people, via rapid excretion of bioactive intermediates.
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