Ascorbate (vitamin C) induces cell death through the apoptosis-inducing factor in human breast cancer cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Seung-Woo | - |
dc.contributor.author | Jin, Dong-Hoon | - |
dc.contributor.author | Hahm, Eun-Sil | - |
dc.contributor.author | Yim, Sei-Hyun | - |
dc.contributor.author | Lim, Jong-Seok | - |
dc.contributor.author | Kim, Keun-Il | - |
dc.contributor.author | Yang, Young | - |
dc.contributor.author | Lee, Soo-Suk | - |
dc.contributor.author | Kang, Jae-Seung | - |
dc.contributor.author | Lee, Wang-Jae | - |
dc.contributor.author | Lee, Won-Keun | - |
dc.contributor.author | Lee, Myeong-Sok | - |
dc.date.available | 2021-02-22T11:13:33Z | - |
dc.date.issued | 2007-10 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.issn | 1791-2431 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/8342 | - |
dc.description.abstract | Although ascorbate (Vitamin C) has been shown to inhibit cell growth and induce cell death in variety of cancer cells, results reported in other studies are inconsistent with this conclusion. It was previously reported that ascorbate induces apoptosis in human breast cancer cells. However, the molecular mechanism for this is not clear. In this study, we demonstrate that ascorbate induces cell death through the apoptosis-inducing factor (AIF) in the human breast cancer cell lines, SK-BR3 and Hs578T, but not in a normal breast cell line, Hs578. Ascorbate treatment caused the nuclear translocation of AIF, which is retained in the mitochondria in healthy cells, but caspase cleavage is not induced. Moreover, MG132, an inhibitor of AIF release from mitochondria, blocked the induction of cell death. Furthermore, cells that had been treated with human AIF-specific siRNA resisted cell death induced by ascorbate, implying that the translocation of AIF from mitochondria to the nucleus is responsible for ascorbate-mediated cell death. Therefore, these results suggest that ascorbate activates a caspase-independent and AIF-mediated cell death pathway in human breast cancer cells, SK-BR3, and Hs578T. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.title | Ascorbate (vitamin C) induces cell death through the apoptosis-inducing factor in human breast cancer cells | - |
dc.type | Article | - |
dc.publisher.location | 그리이스 | - |
dc.identifier.doi | 10.3892/or.18.4.811 | - |
dc.identifier.scopusid | 2-s2.0-38449117512 | - |
dc.identifier.wosid | 000249771800009 | - |
dc.identifier.bibliographicCitation | ONCOLOGY REPORTS, v.18, no.4, pp 811 - 815 | - |
dc.citation.title | ONCOLOGY REPORTS | - |
dc.citation.volume | 18 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 811 | - |
dc.citation.endPage | 815 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | MITOCHONDRIAL CONTROL | - |
dc.subject.keywordPlus | NEUROBLASTOMA-CELLS | - |
dc.subject.keywordPlus | ENDONUCLEASE-G | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | LINES | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordAuthor | ascorbate (vitamin C) | - |
dc.subject.keywordAuthor | apoptosis-inducing factor | - |
dc.subject.keywordAuthor | caspase | - |
dc.subject.keywordAuthor | cell death | - |
dc.subject.keywordAuthor | Ca2+ | - |
dc.identifier.url | https://www.spandidos-publications.com/10.3892/or.18.4.811 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.