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An endoplasmic reticulum-selective ratiometric fluorescent probe for imaging a copper pool
- Authors
- Park, Sun Young; Kim, Woori; Park, Sun-Hee; Han, Jinhyoung; Lee, Jinju; Kang, Chulhun; Lee, Min Hee
- Issue Date
- Apr-2017
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.53, no.32, pp 4457 - 4460
- Pages
- 4
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 53
- Number
- 32
- Start Page
- 4457
- End Page
- 4460
- ISSN
- 1359-7345
1364-548X
- Abstract
- Hydrazide-linked naphthalimides undergo copper ion-selective hydrolysis with concomitant ratiometric fluorescence change. In addition, probe 1 is biocompatible and mainly localized to the endoplasmic reticulum ( ER) in live HeLa cells. It thus can be used for imaging copper accumulation in the ER of live cells, as implied in copper-overloaded situations.
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