RIGHT DRUGS AND RIGHT PATIENTS-I. PHARMACO-GENOMIC AND-GENETIC APPROACHES FOR EFFICIENT TREATMENT OF 5-FU
DC Field | Value | Language |
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dc.contributor.author | Yang, Mihi | - |
dc.contributor.author | Tae, Kyung | - |
dc.date.available | 2021-02-22T11:17:50Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 1347-4367 | - |
dc.identifier.issn | 1880-0920 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/8920 | - |
dc.description.abstract | 5-fluorouracil (5-FU) has been used as a broad anticancer drug, however, its side effects have been monitored. Therefore, we performed pharmaco-genomic and -genetic studies for right treatment of 5-FU for right patients. As results, we found genetic polymorphisms at metabolic enzymes of 5-FU, e.g. DPYD-85, -1627, and -1896 sites, TS-5'ER, and -3'UTR, and MTHFR-222, and -429 sites among Korean populations (normal, N=105; head and neck patients, N=28). There was a significant association between TS-mRNA levels and the 3'TS-UTR genetic polymorphism (p<0.05). From 5-FU pharmacokinetic (PK) analyses, the above each genotype did not show any effects on PK parameters. However, the combination of genetic polymorphisms at the MTHFR 222T/C, DPYD 1896T/C and 3'TS-UTR showed significant differences in AUC of 5-FU and 5-FU/5-FUD ratios (p<0.01). Therefore, this study provides molecular and clinical evidences for personalized medicine of 5-FU. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | JAPANESE SOC STUDY XENOBIOTICS | - |
dc.title | RIGHT DRUGS AND RIGHT PATIENTS-I. PHARMACO-GENOMIC AND-GENETIC APPROACHES FOR EFFICIENT TREATMENT OF 5-FU | - |
dc.type | Article | - |
dc.publisher.location | 일본 | - |
dc.identifier.doi | 10.1016/j.dmpk.2016.10.249 | - |
dc.identifier.wosid | 000397013800206 | - |
dc.identifier.bibliographicCitation | DRUG METABOLISM AND PHARMACOKINETICS, v.32, no.1_suppl., pp S62 - S62 | - |
dc.citation.title | DRUG METABOLISM AND PHARMACOKINETICS | - |
dc.citation.volume | 32 | - |
dc.citation.number | 1_suppl. | - |
dc.citation.startPage | S62 | - |
dc.citation.endPage | S62 | - |
dc.type.docType | Meeting Abstract | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/abs/pii/S1347436716303639?via%3Dihub | - |
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