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Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patientsopen access

Authors
Seo, Seung HeeKim, Sung-EunKang, Yoon-KooRyoo, Baek-YeolRyu, Min-HeeJeong, Jae HoKang, Shin SookYang, MihiLee, Jung EunSung, Mi-Kyung
Issue Date
Nov-2016
Publisher
BIOMED CENTRAL LTD
Keywords
Gastric cancer; Malnutrition; Chemotherapy; Adverse events; Hypoalbuminemia
Citation
BMC CANCER, v.16, pp 1 - 9
Pages
9
Journal Title
BMC CANCER
Volume
16
Start Page
1
End Page
9
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/9376
DOI
10.1186/s12885-016-2934-5
ISSN
1471-2407
Abstract
Background: Malnutrition in gastrectomized patients receiving chemotherapy is associated with the susceptibility to chemotherapy-related adverse events. This study evaluated pre-operative nutritional status-related indices associated with adverse events in post-operation gastric cancer patients receiving chemotherapy. Methods: Medical records of 234 gastrectomized patients under adjuvant tegafur/gimeracil/oteracil chemotherapy with extended lymph node dissection were analyzed. Nutritional status assessment included Patient-Generated Subjective Global Assessment (PG-SGA), body weight, body mass index, serum albumin concentration, and Nutrition Risk Index (NRI). Chemotherapy-originated adverse events were determined using Common Terminology Criteria for Adverse Events. Results: PG-SGA indicated 59% of the patients were malnourished, and 27.8% of the patients revealed serious malnutrition with PG-SGA score of = 9. Fifteen % of patients lost = 10% of the initial body weight, 14.5% of the patients had hypoalbuminemia (< 3.5 g/dL), and 66.2% had NRI score less than 97.5 indicating moderate to severe malnutrition. Hematological adverse events were present in 94% (= grade 1) and 16.2% (= grade 3). Non-hematological adverse events occurred in 95.7% (= grade1) and 16.7% (= grade 3) of the patients. PG-SGA and NRI score was not associated with treatment-induced adverse events. Multivariate analyses indicated that female, low body mass index, and hypoalbuminemia were independent risk factors for grade 3/4 hematological adverse events. Age was an independent risk factor for grade 3/4 non-hematological adverse events. Neutropenia was the most frequently occurring adverse event, and associated risk factors were female, total gastrectomy, and hypoalbuminemia. Conclusions: Hypoalbuminemia, not PG-SGA or NRI may predict chemotherapy-induced adverse events in gastrectomized cancer patients.
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약학대학 > 약학부 > 1. Journal Articles
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