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Acid-triggered release of doxorubicin from a hydrazone-linked Gd3+-texaphyrin conjugate

Authors
Lee, Min HeeKim, Eun-JoongLee, HyunseungPark, Sun YoungHong, Kwan SooKim, Jong SeungSessler, Jonathan L.
Issue Date
Sep-2016
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL COMMUNICATIONS, v.52, no.69, pp 10551 - 10554
Pages
4
Journal Title
CHEMICAL COMMUNICATIONS
Volume
52
Number
69
Start Page
10551
End Page
10554
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/9449
DOI
10.1039/c6cc05673c
ISSN
1359-7345
1364-548X
Abstract
The hydrazone-based Gd3+-texaphyrin doxorubicin conjugate 1, releases active doxorubicin at acidic pH values, allowing its components to be followed by two complementary imaging methods, namely Off-On fluorescence enhancement and MR imaging. It thus acts as a promising theranostic agent.
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