Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitisopen access
- Authors
- 조대호; 김정은; 김종식; 박현정
- Issue Date
- Aug-2016
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- atopic dermatitis; genetics; epigenomics; barrier; immunologic abnormalities
- Citation
- International Journal of Molecular Sciences, v.17, no.8, pp 1234 - 1263
- Pages
- 30
- Journal Title
- International Journal of Molecular Sciences
- Volume
- 17
- Number
- 8
- Start Page
- 1234
- End Page
- 1263
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/9457
- DOI
- 10.3390/ijms17081234
- ISSN
- 1661-6596
1422-0067
- Abstract
- Atopic dermatitis (AD) is a multifactorial inflammatory skin disease resulting from interactions between genetic susceptibility and environmental factors. The pathogenesis of AD is poorly understood, and the treatment of recalcitrant AD is still challenging. There is accumulating evidence for new gene polymorphisms related to the epidermal barrier function and innate and adaptive immunity in patients with AD. Newly-found T cells and dendritic cell subsets, cytokines, chemokines and signaling pathways have extended our understanding of the molecular pathomechanism underlying AD. Genetic changes caused by environmental factors have been shown to contribute to the pathogenesis of AD. We herein present a review of the genetics, epigenetics, barrier dysfunction and immunological abnormalities in AD with a focus on updated molecular biology.
- Files in This Item
-
Go to Link
- Appears in
Collections - 대학 > 기초교양대학 > 기초교양학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.