생강 추출물 투여가 마우스 면역세포 활성에 미치는 영향

Abstract

Ginger (Zingiber oficinale Roscoe) has been used as a raw material in many traditional preparations since the ancient time. As a component of traditional health products, Ginger is known to be efective as appetite enhancer, anti-cold and anti-inflammation. This study was performed to investigate the immunomodulative efects of Ginger in mouse, using in vitro and ex vivo experiments. In vitro experiment, the mice splenocytes proliferation and thre kinds of cytokines (IL-1β, IL-6, and TNF-α) prodution by peritoneal macrophages cultured with ethanol and water extracts Ginger ex vivo, water extract of Ginger was oraly administrated into mice, and isolated splencytes and macrophages were used as experimental model. Ex vivo experiment, six to seven week old mice were fed ad libitum on a chow diet, and water extract of Ginger was orally administrated every other day for four weeks at two diferent concentractions (50 and 500 mg/kg B.W./day). In vitro study, the splenocytes proliferation was increased when water extract was suplemented in the range of 50- 500 μ β, IL-6 and TNF-α released by activated peritoneal macrophages were augmented by the suplementation of water extract of the Ginger. Ex vivo experiment, the highest proliferation of splenocytes and production of cytokines by activated peritoneal macrophages were sen in the mice orally administrated at the concentration of 500 mg/kg B.W./day. In conclusion, this study suggests that Ginger extracts may enhance the immune function by regulating the splenocytes proliferation and enhancing the cytokine prodution capacity by activated macrophages in mice. (Korean J Nutrition 37 (1) : 23 ~ 30, 204 )