Detailed Information

Cited 0 time in webofscience Cited 10 time in scopus
Metadata Downloads

Circulating CTRP1 Levels in Type 2 Diabetes and Their Association with FGF21open access

Authors
Han, SoraKim, Jong DaiLee, SunyiJeong, Ae LeePark, Jeong SuYong, Hyo JeongBoldbaatar, AriundavaaKa, Hye InRhee, Eun-JungLee, Won-YoungYang, Young
Issue Date
May-2016
Publisher
HINDAWI LTD
Citation
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, v.2016
Journal Title
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
Volume
2016
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/9808
DOI
10.1155/2016/5479627
ISSN
1687-8337
1687-8345
Abstract
The goal of this study was to investigate whether circulating C1q/TNF-alpha-related protein 1 (CTRP1) levels are associated with diabetes. In addition, relationships between CTRP1 and other diabetes-related cytokines were elucidated, including adiponectin and fibroblast growth factor 21 (FGF21). A total of 178 subjects (78 men and 100 women) aged 29-70 years (mean age, 46.1 years) were randomly selected. The sera from a normal glucose tolerance group (n = 68) and a prediabetes/type 2 diabetes group (n = 110) were collected; then, circulating levels of CTRP1, adiponectin, and FGF21 were determined via enzyme-linked immunosorbent assay in all sera. Subjects with either prediabetes or diabetes exhibited higher circulating CTRP1 levels than healthy subjects. Sera analysis revealed that CTRP1 was positively correlated with age, body mass index, fasting blood glucose, and circulating FGF21 levels. However, CTRP1 was negatively correlated with total cholesterol and total circulating adiponectin levels in univariate analysis. In addition, multivariate analysis found that CTRP1 was independently associated with age, fasting blood glucose, and circulating FGF21 levels. CTRP1 was correlated with homeostasis model assessment-beta (HOMA-beta), but no correlation was observed with HOMA-insulin resistance. In conclusion, circulating CTRP1 levels are increased in subjects with type 2 diabetes and are positively associated with circulating FGF21 levels.
Files in This Item
Go to Link
Appears in
Collections
이과대학 > 생명시스템학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Yang, Young photo

Yang, Young
이과대학 (생명시스템학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE