Detailed Information

Cited 0 time in webofscience Cited 2 time in scopus
Metadata Downloads

Effect of obesity on the association between MYL2 (rs3782889) and high-density lipoprotein cholesterol among Korean men

Authors
Cho, Eo RinJee, Yon HoKim, Sang WonSull, Jae Woong
Issue Date
May-2016
Publisher
NATURE PUBLISHING GROUP
Citation
JOURNAL OF HUMAN GENETICS, v.61, no.5, pp 405 - 409
Pages
5
Journal Title
JOURNAL OF HUMAN GENETICS
Volume
61
Number
5
Start Page
405
End Page
409
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/9819
DOI
10.1038/jhg.2015.165
ISSN
1434-5161
1435-232X
Abstract
High-density lipoprotein (HDL) cholesterol levels are associated with a decreased risk of coronary artery disease. Several genome-wide association studies that have examined HDL cholesterol levels have implicated myosin light chain 2 regulatory cardiac slow (MYL2) as a possible causal factor. Herein, the association between the rs3782889 single-nucleotide polymorphism (SNP) in the MYL2 gene and HDL cholesterol levels was tested in the Korean population. A total of 4294 individuals were included in a replication study with MYL2 SNP rs3782889. SNP rs3782889 in the MYL2 gene was associated with mean HDL cholesterol level (effect per allele, -1.055 mg dl(-1), P=0.0005). Subjects with the CT/CC genotype had a 1.43-fold (range 1.19-1.73-fold) higher risk of an abnormal HDL cholesterol level (<40 mg dl(-1)) than subjects with the TT genotype. When analyzed by sex, the MYL2 association was stronger in men than that in women. When analyzed by body mass index (BMI), the MYL2 association was much stronger in male subjects with BMI >= 26.44 kg m(-2) (odds ratio (OR)=2.68; 95% confidence interval (CI)=1.87-3.84; P<0.0001) than that in male subjects with BMI <26.44 kg m(-2). When compared with subjects having the TT genotype and BMI <26.44 kg m(-2), ORs (95% CI) were 3.30 (2.41-4.50) in subjects having the CT/CC genotype and BMI >= 26.44 kg m(-2) (P for interaction <0.0001). Our results clearly demonstrate that genetic variants in MYL2 influence HDL cholesterol levels in Korean obese male subjects.
Files in This Item
Go to Link
Appears in
Collections
이과대학 > 통계학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE