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Decursin from Angelica gigas suppresses RANKL-induced osteoclast formation and bone loss

Authors
Wang, XinZheng, TingKang, Ju-HeeLi, HuaCho, HyewonJeon, RaokRyu, Jae-HaYim, Mijung
Issue Date
Mar-2016
Publisher
ELSEVIER SCIENCE BV
Keywords
Angelica gigas; Decursin; Osteoclast; NFATc1; c-Fos; Bone loss
Citation
European Journal of Pharmacology, v.774, pp 34 - 42
Pages
9
Journal Title
European Journal of Pharmacology
Volume
774
Start Page
34
End Page
42
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/9901
DOI
10.1016/j.ejphar.2016.01.008
ISSN
0014-2999
1879-0712
Abstract
Osteoclasts are the only cells capable of breaking down bone matrix, and excessive activation of osteoclasts is responsible for bone-destructive diseases. In this study, we investigated the effects of decursin from extract of Angelica gigas root on receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclast formation using mouse bone marrow-derived macrophages (BMMs). Decursin inhibited RANKL-induced osteoclast formation without cytotoxicity. In particular, decursin maintains the characteristics of macrophages by blocking osteoclast differentiation by RANKL. Furthermore, the RANKL-stimulated bone resorption was diminished by decursin. Mechanistically, decursin blocked the RANKL-triggered ERK mitogen-activated protein kinases (MAPK) phosphorylation, which results in suppression of c-Fos and the nuclear factor of activated T cells (NFATc1) expression. In accordance with the in vitro study, decursin reduced lipopolysaccharide (LPS)- or ovariectomy (OVX)-induced bone loss in vivo. Therefore, decursin exerted an inhibitory effect on osteoclast formation and bone loss in vitro and in vivo. Decursin could be useful for the treatment of bone diseases associated with excessive bone resorption. (C) 2016 Elsevier B.V. All rights reserved.
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