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Erythroid differentiation regulator 1 ameliorates collagen-induced arthritis via activation of regulatory t cells

Authors
Kim, Myun SooLee, SoraPark, SunyoungKim, Kyung EunPark, Hyun JeongCho, Daeho
Issue Date
Dec-2020
Publisher
MDPI AG
Keywords
Erythroid differentiation regulator 1; Regulatory T cells; Rheumatoid arthritis
Citation
International Journal of Molecular Sciences, v.21, no.24, pp 1 - 10
Pages
10
Journal Title
International Journal of Molecular Sciences
Volume
21
Number
24
Start Page
1
End Page
10
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/991
DOI
10.3390/ijms21249555
ISSN
1661-6596
1422-0067
Abstract
Erythroid differentiation regulator 1 (Erdr1) has been identified as an anti-inflammatory factor in several disease models, including collagen-induced arthritis (CIA), but its exact mechanisms are still not fully understood. Here, the involvement of regulatory T (Treg) cells in Erdr1-improved CIA was investigated. In the CIA model, Erdr1 was confirmed to reduce collagen-specific IgM in plasma and plasma cells in draining lymph nodes. Importantly, the downregulated Treg cell ratio in draining lymph nodes from CIA mice was recovered by Erdr1 treatment. In addition, administration of Erdr1 improved the CIA score and joint tissue damage, while it revealed no effect in Treg cell-depleted CIA mice, indicating that Treg cells mediate the therapeutic effects of Erdr1 in the CIA model. Results from in vitro experiments also demonstrated that Erdr1 significantly induced Treg cell differentiation and the expression of Treg activation markers, including CD25, CD69, and CTLA4 in CD4+ Foxp3+ cells. Furthermore, Erdr1-activated Treg cells dramatically suppressed the proliferation of responder T cells, suggesting that they are functionally active. Taken together, these results show that Erdr1 induces activation of Treg cells and ameliorates rheumatoid arthritis via Treg cells. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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Kim, Kyung Eun
대학원 (헬스산업학(협동과정))
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