Erythroid differentiation regulator 1 ameliorates collagen-induced arthritis via activation of regulatory t cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Myun Soo | - |
dc.contributor.author | Lee, Sora | - |
dc.contributor.author | Park, Sunyoung | - |
dc.contributor.author | Kim, Kyung Eun | - |
dc.contributor.author | Park, Hyun Jeong | - |
dc.contributor.author | Cho, Daeho | - |
dc.date.available | 2021-02-22T04:57:13Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/991 | - |
dc.description.abstract | Erythroid differentiation regulator 1 (Erdr1) has been identified as an anti-inflammatory factor in several disease models, including collagen-induced arthritis (CIA), but its exact mechanisms are still not fully understood. Here, the involvement of regulatory T (Treg) cells in Erdr1-improved CIA was investigated. In the CIA model, Erdr1 was confirmed to reduce collagen-specific IgM in plasma and plasma cells in draining lymph nodes. Importantly, the downregulated Treg cell ratio in draining lymph nodes from CIA mice was recovered by Erdr1 treatment. In addition, administration of Erdr1 improved the CIA score and joint tissue damage, while it revealed no effect in Treg cell-depleted CIA mice, indicating that Treg cells mediate the therapeutic effects of Erdr1 in the CIA model. Results from in vitro experiments also demonstrated that Erdr1 significantly induced Treg cell differentiation and the expression of Treg activation markers, including CD25, CD69, and CTLA4 in CD4+ Foxp3+ cells. Furthermore, Erdr1-activated Treg cells dramatically suppressed the proliferation of responder T cells, suggesting that they are functionally active. Taken together, these results show that Erdr1 induces activation of Treg cells and ameliorates rheumatoid arthritis via Treg cells. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | Erythroid differentiation regulator 1 ameliorates collagen-induced arthritis via activation of regulatory t cells | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/ijms21249555 | - |
dc.identifier.scopusid | 2-s2.0-85098229130 | - |
dc.identifier.wosid | 000602887900001 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.21, no.24, pp 1 - 10 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 21 | - |
dc.citation.number | 24 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | antiinflammatory agent | - |
dc.subject.keywordPlus | CD4 antigen | - |
dc.subject.keywordPlus | CD69 antigen | - |
dc.subject.keywordPlus | collagen type 2 | - |
dc.subject.keywordPlus | cytotoxic T lymphocyte antigen 4 | - |
dc.subject.keywordPlus | erythroid differentiation regulator 1 protein | - |
dc.subject.keywordPlus | immunoglobulin M | - |
dc.subject.keywordPlus | interleukin 2 receptor alpha | - |
dc.subject.keywordPlus | methotrexate | - |
dc.subject.keywordPlus | recombinant protein | - |
dc.subject.keywordPlus | transcription factor FOXP3 | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | antigen expression | - |
dc.subject.keywordPlus | antiinflammatory activity | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | CD4+ T lymphocyte | - |
dc.subject.keywordPlus | collagen-induced arthritis | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | down regulation | - |
dc.subject.keywordPlus | draining lymph node | - |
dc.subject.keywordPlus | immunoglobulin blood level | - |
dc.subject.keywordPlus | in vitro study | - |
dc.subject.keywordPlus | lymphocyte differentiation | - |
dc.subject.keywordPlus | lymphocyte proliferation | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | plasma | - |
dc.subject.keywordPlus | plasma cell | - |
dc.subject.keywordPlus | regulatory T lymphocyte | - |
dc.subject.keywordPlus | rheumatoid arthritis | - |
dc.subject.keywordPlus | T cell depletion | - |
dc.subject.keywordPlus | T lymphocyte activation | - |
dc.subject.keywordPlus | tissue injury | - |
dc.subject.keywordAuthor | Erythroid differentiation regulator 1 | - |
dc.subject.keywordAuthor | Regulatory T cells | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.identifier.url | https://www.mdpi.com/1422-0067/21/24/9555 | - |
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