Detailed Information

Cited 2 time in webofscience Cited 3 time in scopus
Metadata Downloads

Erythroid differentiation regulator 1 ameliorates collagen-induced arthritis via activation of regulatory t cells

Full metadata record
DC Field Value Language
dc.contributor.authorKim, Myun Soo-
dc.contributor.authorLee, Sora-
dc.contributor.authorPark, Sunyoung-
dc.contributor.authorKim, Kyung Eun-
dc.contributor.authorPark, Hyun Jeong-
dc.contributor.authorCho, Daeho-
dc.date.available2021-02-22T04:57:13Z-
dc.date.issued2020-12-
dc.identifier.issn1661-6596-
dc.identifier.issn1422-0067-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/991-
dc.description.abstractErythroid differentiation regulator 1 (Erdr1) has been identified as an anti-inflammatory factor in several disease models, including collagen-induced arthritis (CIA), but its exact mechanisms are still not fully understood. Here, the involvement of regulatory T (Treg) cells in Erdr1-improved CIA was investigated. In the CIA model, Erdr1 was confirmed to reduce collagen-specific IgM in plasma and plasma cells in draining lymph nodes. Importantly, the downregulated Treg cell ratio in draining lymph nodes from CIA mice was recovered by Erdr1 treatment. In addition, administration of Erdr1 improved the CIA score and joint tissue damage, while it revealed no effect in Treg cell-depleted CIA mice, indicating that Treg cells mediate the therapeutic effects of Erdr1 in the CIA model. Results from in vitro experiments also demonstrated that Erdr1 significantly induced Treg cell differentiation and the expression of Treg activation markers, including CD25, CD69, and CTLA4 in CD4+ Foxp3+ cells. Furthermore, Erdr1-activated Treg cells dramatically suppressed the proliferation of responder T cells, suggesting that they are functionally active. Taken together, these results show that Erdr1 induces activation of Treg cells and ameliorates rheumatoid arthritis via Treg cells. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.-
dc.format.extent10-
dc.language영어-
dc.language.isoENG-
dc.publisherMDPI AG-
dc.titleErythroid differentiation regulator 1 ameliorates collagen-induced arthritis via activation of regulatory t cells-
dc.typeArticle-
dc.publisher.location스위스-
dc.identifier.doi10.3390/ijms21249555-
dc.identifier.scopusid2-s2.0-85098229130-
dc.identifier.wosid000602887900001-
dc.identifier.bibliographicCitationInternational Journal of Molecular Sciences, v.21, no.24, pp 1 - 10-
dc.citation.titleInternational Journal of Molecular Sciences-
dc.citation.volume21-
dc.citation.number24-
dc.citation.startPage1-
dc.citation.endPage10-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.subject.keywordPlusantiinflammatory agent-
dc.subject.keywordPlusCD4 antigen-
dc.subject.keywordPlusCD69 antigen-
dc.subject.keywordPluscollagen type 2-
dc.subject.keywordPluscytotoxic T lymphocyte antigen 4-
dc.subject.keywordPluserythroid differentiation regulator 1 protein-
dc.subject.keywordPlusimmunoglobulin M-
dc.subject.keywordPlusinterleukin 2 receptor alpha-
dc.subject.keywordPlusmethotrexate-
dc.subject.keywordPlusrecombinant protein-
dc.subject.keywordPlustranscription factor FOXP3-
dc.subject.keywordPlusunclassified drug-
dc.subject.keywordPlusanimal cell-
dc.subject.keywordPlusanimal experiment-
dc.subject.keywordPlusanimal model-
dc.subject.keywordPlusanimal tissue-
dc.subject.keywordPlusantigen expression-
dc.subject.keywordPlusantiinflammatory activity-
dc.subject.keywordPlusArticle-
dc.subject.keywordPlusCD4+ T lymphocyte-
dc.subject.keywordPluscollagen-induced arthritis-
dc.subject.keywordPluscontrolled study-
dc.subject.keywordPlusdown regulation-
dc.subject.keywordPlusdraining lymph node-
dc.subject.keywordPlusimmunoglobulin blood level-
dc.subject.keywordPlusin vitro study-
dc.subject.keywordPluslymphocyte differentiation-
dc.subject.keywordPluslymphocyte proliferation-
dc.subject.keywordPlusmale-
dc.subject.keywordPlusmouse-
dc.subject.keywordPlusnonhuman-
dc.subject.keywordPlusplasma-
dc.subject.keywordPlusplasma cell-
dc.subject.keywordPlusregulatory T lymphocyte-
dc.subject.keywordPlusrheumatoid arthritis-
dc.subject.keywordPlusT cell depletion-
dc.subject.keywordPlusT lymphocyte activation-
dc.subject.keywordPlustissue injury-
dc.subject.keywordAuthorErythroid differentiation regulator 1-
dc.subject.keywordAuthorRegulatory T cells-
dc.subject.keywordAuthorRheumatoid arthritis-
dc.identifier.urlhttps://www.mdpi.com/1422-0067/21/24/9555-
Files in This Item
Go to Link
Appears in
Collections
원격대학원 > 향장미용학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Kyung Eun photo

Kim, Kyung Eun
대학원 (헬스산업학(협동과정))
Read more

Altmetrics

Total Views & Downloads

BROWSE