Detailed Information

Cited 0 time in webofscience Cited 19 time in scopus
Metadata Downloads

Cellular prion protein regulates invasion and migration of breast cancer cells through MMP-9 activity

Authors
Gil, MinchanKim, Yun KyeKim, Kyung-EunKim, WookPark, Chan-SikLee, Kyung Jin
Issue Date
Jan-2016
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Prion; Matrix metalloprotease-9; Migration; Invasion; Breast cancer
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.470, no.1, pp 213 - 219
Pages
7
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
470
Number
1
Start Page
213
End Page
219
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/9980
DOI
10.1016/j.bbrc.2016.01.038
ISSN
0006-291X
1090-2104
Abstract
Function of cellular prion protein (PrPc) in cancer progression has not been elucidated yet. Ectopic expression of PrPc increases the invasion and migration of breast cancer cell line, MCF-7 cells. Over-expressed PrPc increases matrix metalloprotease-9 (MMP-9) expression by enhancing association of NF-kappa B in promoter of MMP-9 gene and ERK signaling in MCF-7 cells. Whereas, silencing of PrPc by siRNA suppresses ERK activation and MMP-9 expression resulting the down-regulation of MD-MB231 cell migration and invasion. Overall, these results suggest that PrPc contribute the breast cancer invasion and migration via MMP-9. (C) 2016 Elsevier Inc. All rights reserved.
Files in This Item
Go to Link
Appears in
Collections
원격대학원 > 향장미용학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Kyung Eun photo

Kim, Kyung Eun
대학원 (헬스산업학(협동과정))
Read more

Altmetrics

Total Views & Downloads

BROWSE