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Diosmetin and its glycoside, diosmin, improve atopic dermatitis-like lesions in 2,4-dinitrochlorobenzene-induced murine models

Authors
Park, Sang-aBong, Sim-KyuLee, Jin WooPark, No-JuneChoi, YongsooKim, Sang MooYang, Min HyeKim, Yong KeeKim, Su-Nam
Issue Date
Jan-2020
Publisher
Korean Society of Applied Pharmacologyeditor@biomolther.org
Keywords
Diosmetin; Diosmin; Atopic dermatitis; IL-4; DNCB
Citation
Biomolecules and Therapeutics, v.28, no.6, pp 542 - 548
Pages
7
Journal Title
Biomolecules and Therapeutics
Volume
28
Number
6
Start Page
542
End Page
548
URI
https://scholarworks.sookmyung.ac.kr/handle/2021.sw.sookmyung/818
DOI
10.4062/biomolther.2020.135
ISSN
1976-9148
2005-4483
Abstract
Naturally derived diosmetin and its glycoside diosmin are known to be effective in treating inflammatory disease. This study was performed to determine whether diosmin and diosmetin have the effect of improving atopic dermatitis in a 2,4-dinitrochlorobenzen (DNCB)-induced atopic dermatitis (AD) model. DNCB was used to establish AD model in hairless mice. Skin moisture, serum im-munoglobulin E (IgE), interleukin 4 (IL-4), and histological analysis were performed to measure the effectiveness of diosmin and diosmetine to improve AD. IL-4 levels were also measured in RBL-2H3 cells. Administration of diosmetin or diosmin orally inhibited the progress of DNCB-induced AD-like lesions in murine models by inhibiting transdermal water loss (TEWL) and increasing skin hydration. Diosmetin or diosmin treatment also reduced IgE and IL-4 levels in AD-induced hairless mouse serum samples. How-ever, in the in vitro assay, only diosmetin, not diosmin, reduced the expression level of IL-4 mRNA in RBL-2H3 cells. Diosmin and diosmetine alleviated the altered epidermal thickness and immune cell infiltration in AD. Diosmin is considered effective in the cure of AD and skin inflammatory diseases by being converted into diosmetin in the body by pharmacokinetic metabolism. Thus, oral administration of diosmetin and diosmin might be a useful agent for the treatment of AD and cutaneous inflammatory diseases.
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