상세 보기
- Lee, Hwa Jin;
- Li, Hua;
- Chang, Hee Ryun;
- Jung, Hyeyoun;
- Lee, Da Yeon;
- 외 1명
WEB OF SCIENCE
8SCOPUS
14초록
Microglial activation has been associated with neurodegenerative diseases by inducing the neuroinflammatory mediators such as nitric oxide (NO), TNF-alpha and IL-1 beta. (-)-Nyasol, a norlignan isolated from a medicinal plant Anemarrhena asphodeloides, showed anti-inflammatory potential in lipopolysaccharide (LPS)-activated BV-2 microglial cells. (-)-Nyasol inhibited the production of NO and prostaglandin E-2 (PGE(2)) and also the expression of inducible nitric oxide synthase and cyclooxygenase-2, which are responsible for the respective production of NO and PGE(2). It also suppressed the mRNA levels of TNF-alpha and IL-1 beta in activated microglial cells. These effects of (-)-nyasol were correlated with the inactivation of p38 MAPK and the suppression of LPS-induced I-kappa B alpha degradation. Taken together, these results suggest that (-)-nyasol can be a modulator in neuroinflammatory conditions induced by microglial activation.
키워드
- 제목
- (-)-Nyasol, isolated from Anemarrhena asphodeloides suppresses neuroinflammatory response through the inhibition of I-kappa B alpha degradation in LPS-stimulated BV-2 microglial cells
- 저자
- Lee, Hwa Jin; Li, Hua; Chang, Hee Ryun; Jung, Hyeyoun; Lee, Da Yeon; Ryu, Jae-Ha
- 발행일
- 2013-10
- 유형
- Article
- 권
- 28
- 호
- 5
- 페이지
- 954 ~ 959