상세 보기
- Lee, Sunyi;
- Jeong, Ae Lee;
- Park, Jeong Su;
- Han, Sora;
- Jang, Chang-Young;
- ... Kim, Keun Il;
- ... Kim, Yonghwan;
- ... Yang, Young;
- 외 3명
WEB OF SCIENCE
7SCOPUS
7초록
Aurora B activation is triggered at the mitotic entry and required for proper microtubule-kinetochore attachment at mitotic phase. Therefore, Aurora B should be in inactive form in interphase to prevent aberrant cell cycle progression. However, it is unclear how the inactivation of Aurora B is sustained during interphase. In this study, we find that IK depletion-induced mitotic arrest leads to G2 arrest by Aurora B inhibition, indicating that IK depletion enhances Aurora B activation before mitotic entry. IK binds to Aurora B, and colocalizes on the nuclear foci during interphase. Our data further show that IK inhibits Aurora B activation through recruiting PP2A into IK and Aurora B complex. It is thus believed that IK, as a scaffold protein, guides PP2A into Aurora B to suppress its activity in interphase until mitotic entry.
키워드
- 제목
- IK-guided PP2A suppresses Aurora B activity in the interphase of tumor cells
- 저자
- Lee, Sunyi; Jeong, Ae Lee; Park, Jeong Su; Han, Sora; Jang, Chang-Young; Kim, Keun Il; Kim, Yonghwan; Park, Jong Hoon; Lim, Jong-Seok; Lee, Myung Sok; Yang, Young
- 발행일
- 2016-09
- 유형
- Article
- 권
- 73
- 호
- 17
- 페이지
- 3375 ~ 3386