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초록
Based on fluorine switch approach, a series of 3'-fluoropenciclovir analogues with different purine and pyrimidine bases were designed and synthesized. Direct reduction of beta-fluoroester to the corresponding 3-fluoroalcohol provided an easy and new entry pathway towards the synthesis of 3'-fluoropenciclovir analogues. The synthesized X-fluoropenciclovir analogues were evaluated for their antiviral activities against the poliovirus, HSV-1, HSV-2 and HIV.
키워드
Antiviral; Fluorine switch; Penciclovir; 3 '-Fluoropenciclovir; OPEN-CHAIN ANALOGS; NUCLEOSIDES; NEPLANOCIN
- 제목
- Design and Synthesis of 3 '-Fluoropenciclovir Analogues as Antiviral Agents
- 저자
- Choi, Myung-Hee; Lee, Chong-Kyo; Kim, Hee-Doo
- 발행일
- 2010-02
- 유형
- Article
- 권
- 33
- 호
- 2
- 페이지
- 197 ~ 202