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In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii
- Kim, Jae Yeon;
- Lim, Hyo Jin;
- Lee, Da Yeon;
- Kim, Ji Sun;
- Kim, Do Hee;
- ... Jeon, Raok;
- 외 3명
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The overproduction of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) causes neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Four lignans, (+)-eudesmin (1), (+)-magnolin (2), (+)yangambin (3) and a new structure named as epimagnolin B (4) were isolated from Magnolia fargesii (Magnoliaceae) as the inhibitors of NO production in LPS-activated microglia. The most potent compound 4 inhibited the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappa B-alpha degradation and nuclear translocation of p65 subunit of NF-kappa B. (C) 2009 Published by Elsevier Ltd.
키워드
Magnolia fargesii; Nitric oxide; Prostaglandin E-2; Microglia; NITRIC-OXIDE SYNTHASES; FLOWER BUDS; SELECTIVE INHIBITOR; FLOS-MAGNOLIAE; LIPOPOLYSACCHARIDE; STEREOCHEMISTRY; EXPRESSION; CYCLOOXYGENASE-2; DERIVATIVES; ASSIGNMENT
- 제목
- In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii
- 저자
- Kim, Jae Yeon; Lim, Hyo Jin; Lee, Da Yeon; Kim, Ji Sun; Kim, Do Hee; Lee, Hwa Jin; Kim, Hee Doo; Jeon, Raok; Ryu, Jae-Ha
- 발행일
- 2009-02-01
- 유형
- Article
- 권
- 19
- 호
- 3
- 페이지
- 937 ~ 940