ScholarWorks@숙명여자대학교

초록

Feature-based molecular networking analysis suggestedthe presenceof naphthol tetramers in Daldinia childae 047219,the same species but a different strain from one used previously forthe discovery of naphthol trimers promoting adiponectin synthesis.The new tetramers were composed of 5-methoxy-4-naphthol, each of whichwas connected to one another in various positions. Targeted isolationafforded six previously unreported naphthol tetramers (1-6) together with 13 known polyketides (7-19) including naphthol monomers, dimers,and trimers. Structures of the isolated compounds were establishedby using NMR and mass spectroscopic analysis. Nodulisporin A (13), nodulisporin B (14), and 1,1 & PRIME;,3 & PRIME;,3 & DPRIME;-ternaphthalene-5,5 & PRIME;,5 & DPRIME;-trimethoxy-4,4 & PRIME;,4 & DPRIME;-triol(16) demonstrated anti-inflammatory activities againstNO production, but the new compounds were less active.

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