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초록
We have investigated whether extremely low frequency magnetic field (ELF-MF) induces lipid peroxidation and reactive oxygen species in mouse cerebellum. After exposure to 60 Hz ELF-MF at 2.3 mT intensity for 3 hours, there was a significant increase in malondialdehyde level and hydroxyl radical. ELF-MF significantly induced concomitant increase in superoxide dismutase without alteration in glutathione peroxidase activity. While glutathione contents were not altered, ascorbic acid levels were significantly decreased by ELF-MF exposure. These results indicate that ELF-MF may induce oxidative stress in mouse cerebellum. However, the mechanism remains further to be characterized.
키워드
Extremely low frequency magnetic field; Lipid peroxidation; Hydroxyl radical; Superoxide dismutase; Ascorbic acid; FREE-RADICAL PROCESSES; RAT-BRAIN; GLUTATHIONE-PEROXIDASE; OCCUPATIONAL-EXPOSURE; SUPEROXIDE-DISMUTASE; VITAMIN-C; ANTIOXIDANT; HIPPOCAMPUS; INVOLVEMENT; SCAVENGERS
- 제목
- Extremely low frequency magnetic field induces oxidative stress in mouse cerebellum
- 저자
- Chu, Li Y.; Lee, Jong H.; Nam, Yun S.; Lee, Yu J.; Park, Won-Hee; Lee, Byung-Cheon; Kim, Daejin; Chung, Yoon H.; Jeong, Ji H.
- 발행일
- 2011-12
- 유형
- Article
- 권
- 30
- 호
- 4
- 페이지
- 415 ~ 421